Secretaría de Gobernación
CONACYT
INGER
Please use this identifier to cite or link to this item: http://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17287
Title: A noncanonical NF-κB pathway through the p50 subunit regulates Bcl-2 overexpression during an oxidative-conditioning hormesis response
metadata.dc.creator: ARMANDO LUNA LOPEZ
VIRIDIANA YAZMIN GONZALEZ PUERTOS
Jacqueline Romero Ontiveros
JOSE LUIS VENTURA GALLEGOS
ALEJANDRO ZENTELLA DEHESA
LUIS ENRIQUE GOMEZ QUIROZ
MINA KONIGSBERG FAINSTEIN
Keywords: BIOLOGÍA Y QUÍMICA;Ciencias de la vida;Biología celular;Químicos inorgánicos;Radicales libres;Estrés oxidativo;Hormesis;Respuesta adaptativa;Cell biology;Inorganic chemicals;Free radicals;Oxidative stress;Adaptative response
metadata.dc.date: 2013
Publisher: Elsevier
Description: Cells can respond to damage and stress by activating various repair and survival pathways. One of these responses can be induced by preconditioning the cells with sublethal stress to provoke a prosurvival response that will prevent damage and death, and which is known as hormesis. Bcl-2, an antiapoptotic protein recognized by its antioxidant and prosurvival functions, has been documented to play an important role during oxidative-conditioning hormesis. Using an oxidative-hormetic model, which was previously established in the L929 cell line by subjecting the cells to a mild oxidative stress of 50 μM H₂O₂ for 9 h, we identified two different transductional mechanisms that participate in the regulation of Bcl-2 expression during the hormetic response. These mechanisms converge in activating the nuclear transcription factor NF-κB. Interestingly, the noncanonical p50 subunit of the NF-κB family is apparently the subunit that participates during the oxidative-hormetic response.
URI: http://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17287
Appears in Collections:1. Artículos

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