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http://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17287| Title: | A noncanonical NF-κB pathway through the p50 subunit regulates Bcl-2 overexpression during an oxidative-conditioning hormesis response |
| metadata.dc.creator: | ARMANDO LUNA LOPEZ VIRIDIANA YAZMIN GONZALEZ PUERTOS Jacqueline Romero Ontiveros JOSE LUIS VENTURA GALLEGOS ALEJANDRO ZENTELLA DEHESA LUIS ENRIQUE GOMEZ QUIROZ MINA KONIGSBERG FAINSTEIN |
| Keywords: | BIOLOGÍA Y QUÍMICA;Ciencias de la vida;Biología celular;Químicos inorgánicos;Radicales libres;Estrés oxidativo;Hormesis;Respuesta adaptativa;Cell biology;Inorganic chemicals;Free radicals;Oxidative stress;Adaptative response |
| metadata.dc.date: | 2013 |
| Publisher: | Elsevier |
| Description: | Cells can respond to damage and stress by activating various repair and survival pathways. One of these responses can be induced by preconditioning the cells with sublethal stress to provoke a prosurvival response that will prevent damage and death, and which is known as hormesis. Bcl-2, an antiapoptotic protein recognized by its antioxidant and prosurvival functions, has been documented to play an important role during oxidative-conditioning hormesis. Using an oxidative-hormetic model, which was previously established in the L929 cell line by subjecting the cells to a mild oxidative stress of 50 μM H₂O₂ for 9 h, we identified two different transductional mechanisms that participate in the regulation of Bcl-2 expression during the hormetic response. These mechanisms converge in activating the nuclear transcription factor NF-κB. Interestingly, the noncanonical p50 subunit of the NF-κB family is apparently the subunit that participates during the oxidative-hormetic response. |
| URI: | http://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17287 |
| Appears in Collections: | 1. Artículos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Free Radical Biology and Medicine (0891-5849) Vol. 63 (2013).pdf | 2.02 MB | Adobe PDF | View/Open |