A noncanonical NF-κB pathway through the p50 subunit regulates Bcl-2 overexpression during an oxidative-conditioning hormesis response

ARMANDO LUNA LOPEZ; VIRIDIANA YAZMIN GONZALEZ PUERTOS; Jacqueline Romero Ontiveros; JOSE LUIS VENTURA GALLEGOS; ALEJANDRO ZENTELLA DEHESA; LUIS ENRIQUE GOMEZ QUIROZ; MINA KONIGSBERG FAINSTEIN

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Campo DC	Valor	Lengua/Idioma
dc.rights.license	http://creativecommons.org/licenses/by/4.0	es_MX
dc.creator	ARMANDO LUNA LOPEZ	es_MX
dc.creator	VIRIDIANA YAZMIN GONZALEZ PUERTOS	es_MX
dc.creator	Jacqueline Romero Ontiveros	es_MX
dc.creator	JOSE LUIS VENTURA GALLEGOS	es_MX
dc.creator	ALEJANDRO ZENTELLA DEHESA	es_MX
dc.creator	LUIS ENRIQUE GOMEZ QUIROZ	es_MX
dc.creator	MINA KONIGSBERG FAINSTEIN	es_MX
dc.date	2013	-
dc.date.accessioned	2021-10-28T18:06:49Z	-
dc.date.available	2021-10-28T18:06:49Z	-
dc.identifier.uri	http://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17287	-
dc.description	Cells can respond to damage and stress by activating various repair and survival pathways. One of these responses can be induced by preconditioning the cells with sublethal stress to provoke a prosurvival response that will prevent damage and death, and which is known as hormesis. Bcl-2, an antiapoptotic protein recognized by its antioxidant and prosurvival functions, has been documented to play an important role during oxidative-conditioning hormesis. Using an oxidative-hormetic model, which was previously established in the L929 cell line by subjecting the cells to a mild oxidative stress of 50 μM H₂O₂ for 9 h, we identified two different transductional mechanisms that participate in the regulation of Bcl-2 expression during the hormetic response. These mechanisms converge in activating the nuclear transcription factor NF-κB. Interestingly, the noncanonical p50 subunit of the NF-κB family is apparently the subunit that participates during the oxidative-hormetic response.	es_MX
dc.format	Adobe PDF	es_MX
dc.language	eng	es_MX
dc.publisher	Elsevier	es_MX
dc.relation	https://www.sciencedirect.com/science/article/abs/pii/S0891584913001913?via%3Dihub#!	es_MX
dc.relation.requires	Si	es_MX
dc.rights	Acceso Abierto	es_MX
dc.source	Free Radical Biology and Medicine (0891-5849) Vol. 63 (2013)	es_MX
dc.subject	BIOLOGÍA Y QUÍMICA	es_MX
dc.subject	Ciencias de la vida	es_MX
dc.subject	Biología celular	es_MX
dc.subject	Químicos inorgánicos	es_MX
dc.subject	Radicales libres	es_MX
dc.subject	Estrés oxidativo	es_MX
dc.subject	Hormesis	es_MX
dc.subject	Respuesta adaptativa	es_MX
dc.subject	Cell biology	es_MX
dc.subject	Inorganic chemicals	es_MX
dc.subject	Free radicals	es_MX
dc.subject	Oxidative stress	es_MX
dc.subject	Adaptative response	es_MX
dc.title	A noncanonical NF-κB pathway through the p50 subunit regulates Bcl-2 overexpression during an oxidative-conditioning hormesis response	es_MX
dc.type	Artículo	es_MX
dc.audience	Researchers	es_MX
dc.creator.id	LULA690630HDFNPR02	es_MX
dc.creator.id	GOPV820119MDFNRR03	es_MX
dc.creator.id	CA1219043	es_MX
dc.creator.id	VEGL670518HGRNLS01	es_MX
dc.creator.id	ZEDA570306HDFNHL05	es_MX
dc.creator.id	GOQL691127HMSMRS00	es_MX
dc.creator.id	KOFM650625MDFNNN02	es_MX
dc.creator.nameIdentifier	curp	es_MX
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dc.creator.nameIdentifier	ca	es_MX
dc.creator.nameIdentifier	curp	es_MX
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dc.creator.nameIdentifier	curp	es_MX
dc.creator.nameIdentifier	curp	es_MX
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