Por favor, use este identificador para citar o enlazar este ítem:
http://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17333| Título : | VNTR polymorphisms of the IL-4 and IL-1RN genes and their relationship with frailty syndrome in Mexican community-dwelling elderly |
| Autor: | THALIA GABRIELA PEREZ SUAREZ LUIS MIGUEL FRANCISCO GUTIERREZ ROBLEDO JOSE ALBERTO AVILA FUNES JOSE LUIS ACOSTA RODRIGUEZ MONICA ESCAMILLA TILCH JORGE RAMON PADILLA GUTIERREZ NORMA TORRES CARRILLO SARA TORRES CASTRO MARIANA LOPEZ ORTEGA Jose Francisco Muñoz Valle NORA MAGDALENA TORRES CARRILLO |
| Palabras clave : | BIOLOGÍA Y QUÍMICA;Geriatría;Personas mayores;Older adults;Fragilidad;Frailty;Predisposición genética;Genetic susceptibility;Polimorfismo VNTR;VNTR polymorphism;México;Mexico |
| Fecha de publicación: | 2016 |
| Editorial : | Elsevier |
| Descripción : | Inflammation is a key event that is closely associated with the pathophysiology of frailty. The relationship of genetic polymorphisms into inflammatory cytokines with frailty remains poorly understood. The aim of this study was to investigate the association between VNTR polymorphisms of the IL-4 and IL-1RN genes with the risk of frailty. We included a sample of 630 community-dwelling elderly aged 70 and older. Both IL-4 and IL-1RN VNTR polymorphisms were genotyped by the polymerase chain reaction (PCR) method. Mean age was 77.7 years (SD = 6.0) and 52.5 % were women. The participants classified as frail were more likely to be older, had lower MMSE score (p < 0.001), and had more disability for IADL (p < 0.001) and ADL (p < 0.001). Genotypic and allelic frequencies for the IL-4 VNTR polymorphism did not show significant differences between study groups (p > 0.05). However, we just observed a significant difference in the allelic frequencies for the A2 allele of the IL-1RN VNTR polymorphism between frail and nonfrail groups (OR 1.84, 95 % CI 1.08-3.12, p = 0.02). In addition, we analyzed the combined effect of the IL-4 and IL-1RN VNTR polymorphisms and their possible association with frailty, where the combined IL-4 (low) -IL-1Ra (high) genotype was identified as a marker of risk to frailty syndrome (OR 7.86, 95 % CI 1.83-33.69, p = 0.006). Our results suggest that both A2 allele and the combined IL-4 (low) -IL-1Ra (high) genotype might be genetic markers of susceptibility to frailty in Mexican elderly. |
| URI : | http://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17333 |
| Aparece en las colecciones: | 1. Artículos |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| Aging Clinical and Experimental Research (1720-8319) Vol. 28 (2016).pdf | 1.39 MB | Adobe PDF | Visualizar/Abrir |