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dc.rights.licensehttp://creativecommons.org/licenses/by/4.0es_MX
dc.creatorADRIANA ALARCON AGUILARes_MX
dc.creatorARMANDO LUNA LOPEZes_MX
dc.creatorJOSE LUIS VENTURA GALLEGOSes_MX
dc.creatorROBERTO CARLOS LAZZARINI LECHUGAes_MX
dc.creatorSONIA GALVAN ARZATEes_MX
dc.creatorVIRIDIANA YAZMIN GONZALEZ PUERTOSes_MX
dc.creatorJulio Morán Andradees_MX
dc.creatorABEL SANTAMARIA DEL ANGELes_MX
dc.creatorMINA KONIGSBERG FAINSTEINes_MX
dc.date2014-
dc.date.accessioned2021-11-01T17:36:56Z-
dc.date.available2021-11-01T17:36:56Z-
dc.identifier.urihttp://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17295-
dc.descriptionAstrocytes are key players for brain physiology, protecting neurons by releasing antioxidant enzymes; however, they are also susceptible to damage by neurotoxins. Nuclear factor erythroid-derived 2-like 2 (Nrf2) is a central regulator of the antioxidant response, and therefore, pharmacologic inducers are often used to activate this transcription factor to induce cellular protection. To date, it still remains unknown if cells from aged animals are capable of developing this response. Therefore, the purpose of this work was to determine if cortical astrocytes derived from old rats are able to respond to tertbuthyl-hydroquinene (tBHQ) pretreatment and stimulate the Nrf2-antioxidant response pathway to induce an antioxidant strategy against MPP+ toxicity, one of the most used molecules to model Parkinson's disease. Our results show that, although astrocytes from adult and old rats were more susceptible to MPP+ toxicity than astrocytes from newborn rats, when pretreated with tertbuthyl-hydroquinene, they were able to transactivate Nrf2, increasing antioxidant enzymes and developing cellular protection. These results are discussed in terms of the doses used to create protective responses.es_MX
dc.formatAdobe PDFes_MX
dc.languageenges_MX
dc.publisherElsevieres_MX
dc.relationhttps://www.sciencedirect.com/science/article/abs/pii/S0197458014001651?via%3Dihubes_MX
dc.relation.requiresSies_MX
dc.rightsAcceso Abiertoes_MX
dc.sourceNeurobiology of Aging (0197-4580) Vol. 35 (2014)es_MX
dc.subjectMEDICINA Y CIENCIAS DE LA SALUDes_MX
dc.subjectCiencias médicases_MX
dc.subjectFarmacodinámicaes_MX
dc.subjectMecanismos de acción de los medicamentoses_MX
dc.subjectSistema nerviosoes_MX
dc.subjectNeurogliaes_MX
dc.subjectAstrocitos (efectos de los medicamentos)es_MX
dc.subjectAstrocitos (metabolismoes_MX
dc.subjectHidroquinonas (farmacología)es_MX
dc.subjectNeurotoxinas (toxicidad)es_MX
dc.subjectEnvejecimientoes_MX
dc.subjectEstrés oxidativoes_MX
dc.subjectNervous systemes_MX
dc.subjectAstrocytes (drug effects)es_MX
dc.subjectAstrocytes (metabolism)es_MX
dc.subjectHydroquinones (pharmacologyes_MX
dc.subjectNeurotoxins (toxicity)es_MX
dc.subjectAginges_MX
dc.subjectOxidative stresses_MX
dc.titlePrimary cultured astrocytes from old rats are capable to activate the Nrf2 response against MPP+ toxicity after tBHQ pretreatmentes_MX
dc.typeArtículoes_MX
dc.audienceResearcherses_MX
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dc.creator.idGOPV820119MDFNRR03es_MX
dc.creator.idCA1218690es_MX
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dc.creator.idKOFM650625MDFNNN02es_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercaes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
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