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http://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17276| Title: | The functional class evaluated in rheumatoid arthritis is associated with soluble TGF-β1 serum levels but not with G915C (Arg25Pro) TGF-β1 polymorphism |
| metadata.dc.creator: | Jose Francisco Muñoz Valle NORA MAGDALENA TORRES CARRILLO IRIS PAOLA GUZMAN GUZMAN NORMA TORRES CARRILLO SANDRA LUZ RUIZ QUEZADA CLAUDIA AZUCENA PALAFOX SANCHEZ HECTOR RANGEL VILLALOBOS MARIA GUADALUPE RAMIREZ DUEÑAS ISELA PARRA ROJAS MARY FAFUTIS MORRIS BLANCA ESTELA BASTIDAS RAMIREZ ANA LAURA PEREIRA SUAREZ |
| Keywords: | BIOLOGÍA Y QUÍMICA;Ciencias de la vida;Genética;Genética humana;Enfermedades reumáticas;Artritis reumatoide;Polimorfismo;TGF-β1;Rheumatic diseases;Rheumatic arthritis;Polumorphism |
| metadata.dc.date: | 2012 |
| Publisher: | Springer |
| Description: | The influence of genetic factors in rheumatoid arthritis (RA) has been described, including several cytokine genes such as transforming growth factor β (TGF-β) with regulatory effects on lymphocytes, dendritic cells, macrophages, chondrocytes, and osteoblasts, which are important in the RA pathogenesis. The G915C TGF-β1 polymorphism has been associated with soluble TGF-β1 (sTGF-β) serum levels. Thus, we studied the association of G915C (Arg25Pro) TGF-β1 polymorphism with sTGF-β1 serum levels in RA. We enrolled 120 RA patients and 120 control subjects (CS). The G915C TGF-β1 polymorphism was determined by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) method, and sTGF-β1 serum levels were quantified using an ELISA kit. The genotype frequency of G915C TGF-β1 polymorphism in RA and CS was G/G (91.7%), G/C (8.3%), C/C (0%) and G/G (85.8%), G/C (14.2%), C/C (0%), respectively, without significant differences. Moreover, the G/G TGF-β1 genotype carriers presented the highest disability index evaluated for the Spanish HAQ-DI score (P < 0.001). In addition, the sTGF-β1 serum levels were higher in RA (182.2 ng/mL) than CS (160.2 ng/mL), there was not significant difference. However, we found a positive correlation between the sTGF-β1 serum levels and the functional class (r = 0.472, P = 0.023). In conclusion, the G915C (Arg25Pro) TGF-β1 polymorphism is not associated with RA, but the sTGF-β1 serum levels are related with the functional class in RA. |
| URI: | http://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17276 |
| Appears in Collections: | 1. Artículos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Rheumatology International (1437-160X) Vol. 32 (2012).pdf | 219.05 kB | Adobe PDF | View/Open |