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http://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17273| Title: | LKTA and PlpE small fragments fusion protein protect against Mannheimia haemolytica challenge |
| metadata.dc.creator: | CAROLINA GUZMAN BRAMBILA MARIA SARAY QUINTERO FABIAN CELIA GONZALEZ CASTILLO ALVARO DE OBESO FERNANDEZ DEL VALLE BEATRIZ FLORES SAMANIEGO GERMAN DE LA MORA RIVAS ARGELIA ESPERANZA ROJAS MAYORQUIN DANIEL ORTUÑO SAHAGUN |
| Keywords: | BIOLOGÍA Y QUÍMICA;Ciencias de la vida;Patología animal;Manheimia haemolytica (inmunología);Complejo bovino respiratorio;Leucotoxina;Biological science disciplines;Biology;Zoology;Pasteurellaceae;Manheimia haemolytica (imminology);Leukotoxin |
| metadata.dc.date: | 2012 |
| Publisher: | Elsevier |
| Description: | Bovine respiratory disease (BRD) complex is a major cause of economic losses for the cattle backgrounding and feedlot industries. Mannheimia haemolytica is considered the most important pathogen associated with this disease. Vaccines against M. haemolytica have been prepared and used for many decades, but traditional bacterins have failed to demonstrate effective protection and their use has often exacerbated disease in vaccinated animals. Thus, the BRD complex continues to exert a strong adverse effect on the health and wellbeing of stocker and feeder cattle. Therefore, generation of recombinant proteins has been helpful in formulating enhanced vaccines against M. haemolytica, which could confer better protection against BRD. In the present study, we formulated a vaccine preparation enriched with recombinant small fragments of leukotoxin A (LKTA) and outer-membrane lipoprotein (PlpE) proteins, and demonstrated its ability to generate high antibody titers in rabbits and sheep, which protected against M. haemolytica bacterial challenge in mice. |
| URI: | http://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17273 |
| Appears in Collections: | 1. Artículos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Research in Veterinary Science (0034-5288) Vol. 93 (2012).pdf | 827.41 kB | Adobe PDF | View/Open |