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dc.rights.licensehttp://creativecommons.org/licenses/by/4.0es_MX
dc.creatorISABEL ARRIETA CRUZes_MX
dc.creatorRaúl Alejandro Librado Osorioes_MX
dc.creatorANGELICA FLORES RAMIREZes_MX
dc.creatorLUCIANO MENDOZA GARCESes_MX
dc.creatorDAVID ROBERTO CHAVIRA RAMIREZes_MX
dc.creatorMARIO CARDENAS LEONes_MX
dc.creatorROGER GUTIERREZ JUAREZes_MX
dc.creatorROBERTO DOMINGUEZ CASALAes_MX
dc.creatorMARIA ESTHER CRUZ BELTRANes_MX
dc.date2019-
dc.date.accessioned2021-08-24T18:29:38Z-
dc.date.available2021-08-24T18:29:38Z-
dc.identifier.urihttp://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17228-
dc.descriptionWe examined the role of the estrogen receptors alpha (ERα) and beta (ERβ) in of the preoptic-anterior hypothalamic area (POA-AHA) in the regulation of ovulation in rats. The number of ERα- and ERβ-immunoreactive (-ir) cells was determined at 09:00, 13:00, and 17:00 h of each stage of the estrous cycle in intact rats. Additionally, the effects of blocking ERα and ERβ on ovulation rate at 09:00 h on diestrus-2 or proestrus day through the microinjection of methyl-piperidino-pyrazole (MPP) or cyclofenil in either side of POA-AHA were evaluated. The number of ERα-ir and ERβ-ir cells in POA-AHA varied in each phase of estrous cycle. Either MPP or cyclofenil in the right side of POA-AHA on diestrus-2 day reduced the ovulation rate, while at proestrus day it was decreased in rats treated in either side with MPP, and in those treated with cyclofenil in the left side. MPP or cyclofenil produced a decrease in the surge of luteinizing hormone levels (LH) and an increase in progesterone and follicle stimulating hormone (FSH). Replacement with synthetic luteinizing hormone-releasing hormone in non-ovulating rats treated with MPP or cyclofenil restored ovulation. These results suggest that activation of estrogen receptors on the morning of diestrus-2 and proestrus day asymmetrically regulates ovulation and appropriately regulates the secretion of FSH and progesterone in the morning and afternoon of proestrus day. This ensures that both, the preovulatory secretion of LH and ovulation, occur at the right time.es_MX
dc.formatAdobe PDFes_MX
dc.languageenges_MX
dc.publisherSpringeres_MX
dc.relationhttps://link.springer.com/article/10.1007%2Fs10571-019-00708-1es_MX
dc.relation.requiresSies_MX
dc.rightsAcceso Abiertoes_MX
dc.sourceCellular and Molecular Neurobiology (1573-6830) Vol. 39 (2019)es_MX
dc.subjectMEDICINA Y CIENCIAS DE LA SALUDes_MX
dc.subjectCiencias médicases_MX
dc.subjectCiencias clínicases_MX
dc.subjectFenómenos fisiológicos reproductivoses_MX
dc.subjectReproducciónes_MX
dc.subjectOvulaciónes_MX
dc.subjectReproductive phsysiological phenomenaes_MX
dc.subjectReproductiones_MX
dc.subjectOvulationes_MX
dc.titleEstrogen receptors alpha and beta in POA-AHA region regulate asymmetrically ovulation.es_MX
dc.typeArtículoes_MX
dc.audienceResearcherses_MX
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dc.creator.idCALM560503HDFRNR05es_MX
dc.creator.idGUJR600202HOCTRG04es_MX
dc.creator.idDOCR390918HNEMSB09es_MX
dc.creator.idCUBE580129MDFRLS07es_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercaes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
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