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Cancer and frailty in older adults: A nested case-control study of the Mexican health and aging study

dc.rights.licensehttp://creativecommons.org/licenses/by/4.0es_MX
dc.creatorMARIO ULISES PEREZ ZEPEDAes_MX
dc.creatorEDUARDO CARDENAS CARDENASes_MX
dc.creatorMatteo Cesaries_MX
dc.creatorANA PATRICIA NAVARRETE REYESes_MX
dc.creatorLUIS MIGUEL FRANCISCO GUTIERREZ ROBLEDOes_MX
dc.date2016
dc.date.accessioned2021-12-06T22:44:21Z
dc.date.available2021-12-06T22:44:21Z
dc.identifier.urihttp://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17331
dc.descriptionPurpose: Understanding how the convergence between chronic and complex diseases-such as cancer-and emerging conditions of older adults-such as frailty-takes place would help in halting the path that leads to disability in this age group. The objective of this manuscript is to describe the association between a past medical history of cancer and frailty in Mexican older adults. Methods: This is a nested in cohort case-control study of the Mexican Health and Aging Study. Frailty was categorized by developing a 55-item frailty index that was also used to define cases in two ways: incident frailty (incident >0.25 frailty index score) and worsening frailty (negative residuals from a regression between 2001 and 2012 frailty index scores). Exposition was defined as self-report of cancer between 2001 and 2012. Older adults with a cancer history were further divided into recently diagnosed (<10 years) and remotely diagnosed (>10 years from the initial diagnosis). Odds ratios were estimated by fitting a logistic regression adjusted for confounding variables. Results: Out of a total of 8022 older adults with a mean age of 70.6 years, the prevalence of a past medical history of cancer was 3.6 % (n = 288). Among these participants, 45.1 % had been diagnosed with cancer more than 10 years previously. A higher risk of incident frailty compared to controls [odds ratio (OR) 1.53 (95 % confidence interval (CI) 1.04-2.26, p = 0.03); adjusted model OR 1.74 (95 % CI 1.15-2.61, p = 0.008)] was found in the group with a recent cancer diagnosis. Also, an inverse association between a remote cancer diagnosis and worsening frailty was found [OR = 0.56 (95 % CI 0.39-0.8), p = 0.002; adjusted model OR 0.61 (95 % CI 0.38-0.99, p = 0.046)]. Conclusions: Cancer is associated with a higher frailty index, with a potential relevant role of the time that has elapsed since the cancer diagnosis. Implications for cancer survivors: Cancer survivors may be more likely to develop frailty or worsening of the health status at an older age. This relationship seems especially evident among individuals with a recent oncological diagnosis. Health professionals in charge of older adult care should be aware of this association in order to improve outcomes of older adults who survived cancer.es_MX
dc.formatAdobe PDFes_MX
dc.languageenges_MX
dc.publisherSpringeres_MX
dc.relationhttps://link.springer.com/article/10.1007%2Fs11764-016-0519-6es_MX
dc.relation.requiresSies_MX
dc.rightsAcceso Abiertoes_MX
dc.sourceJournal of Cancer Survivorship (1932-2267) Vol. 10 (2016)es_MX
dc.subjectMEDICINA Y CIENCIAS DE LA SALUDes_MX
dc.subjectCiencias médicases_MX
dc.subjectCiencias clínicases_MX
dc.subjectGeriatríaes_MX
dc.subjectPersonas mayoreses_MX
dc.subjectOlder adultses_MX
dc.subjectOncogeriatríaes_MX
dc.subjectOncogeriatricses_MX
dc.subjectFragilidades_MX
dc.subjectFrailtyes_MX
dc.subjectEnfermedades crónicases_MX
dc.subjectChronic diseaseses_MX
dc.subjectDiscapacidades_MX
dc.subjectDisabilityes_MX
dc.subjectCánceres_MX
dc.subjectCanceres_MX
dc.subjectMéxicoes_MX
dc.subjectMexicoes_MX
dc.titleCancer and frailty in older adults: A nested case-control study of the Mexican health and aging studyes_MX
dc.typeArtículoes_MX
dc.audienceResearcherses_MX
dc.creator.idPEZM760111HDFRPR07es_MX
dc.creator.idCACE840507HDFRRD02es_MX
dc.creator.id0000-0002-0348-3664es_MX
dc.creator.idNARA790409MJCVYN08es_MX
dc.creator.idGURL571005HDFTBS14es_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercvues_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX


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