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dc.rights.licensehttp://creativecommons.org/licenses/by/4.0es_MX
dc.creatorARMANDO LUNA LOPEZes_MX
dc.creatorVIRIDIANA YAZMIN GONZALEZ PUERTOSes_MX
dc.creatorNORMA EDITH LOPEZ DIAZ GUERREROes_MX
dc.creatorMINA KONIGSBERG FAINSTEINes_MX
dc.date2014-
dc.date.accessioned2021-11-01T18:16:43Z-
dc.date.available2021-11-01T18:16:43Z-
dc.identifier.urihttp://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17299-
dc.descriptionIn order to survive living organisms have developed multiple mechanisms to deal with tough environmental conditions. Hormesis is defined as a process in which exposure to a low dose of a chemical agent or environmental factor that is damaging at higher doses induces an adaptive beneficial effect on the cell or organism. In this paper, we examine several ideas that might be taken into consideration before using hormesis as a therapeutic tool to improve health and life span, and hopefully will open the discussion for new and interesting debates regard hormesis. The first one is to understand that the same stressor or inductor can activate different pathways in a parallel or dual response, which might lead to diverse outcomes. Another idea is related to the mechanisms involved in activating Nrf2, which might be different and have diverse hormetic effects. Last, we discuss mild oxidative stress in association to low-grade chronic inflammation as a stimulating avenue to be explored and the unexpected effects proposed by the obesity paradox theory. All the previous might help to clarify the reasons why centenarians are able to reach the extreme limits of human life span, which could probably be related to the way they deal with homeostasis maintenance, providing an opportunity for hormesis to intervene significantly.es_MX
dc.formatAdobe PDFes_MX
dc.languageenges_MX
dc.publisherSpringer & International CCN Societyes_MX
dc.relationhttps://link.springer.com/article/10.1007/s12079-014-0248-4es_MX
dc.relation.requiresSies_MX
dc.rightsAcceso Abiertoes_MX
dc.sourceJournal of Cell Communication and Signaling (1873-961X) Vol. 8 (2014)es_MX
dc.subjectBIOLOGÍA Y QUÍMICAes_MX
dc.subjectCiencias de la vidaes_MX
dc.subjectEnvejecimientoes_MX
dc.subjectAginges_MX
dc.subjectEstrés oxidativoes_MX
dc.subjectOxidative Stresses_MX
dc.subjectDaño de ADNes_MX
dc.subjectDNA damagees_MX
dc.subjectHormesises_MX
dc.titleNew considerations on hormetic response against oxidative stresses_MX
dc.typeArtículoes_MX
dc.audienceResearcherses_MX
dc.creator.idLULA690630HDFNPR02es_MX
dc.creator.idGOPV820119MDFNRR03es_MX
dc.creator.idLODN680314MDFPZR02es_MX
dc.creator.idKOFM650625MDFNNN02es_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
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