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dc.rights.licensehttp://creativecommons.org/licenses/by/4.0es_MX
dc.creatorFLORENCIA ADRIANA ESPINOSA VALDEZes_MX
dc.creatorMAURA ANGELICA FLORES AGUILARes_MX
dc.creatorISABEL ARRIETA CRUZes_MX
dc.creatorMARIO CARDENAS LEONes_MX
dc.creatorDAVID ROBERTO CHAVIRA RAMIREZes_MX
dc.creatorROBERTO DOMINGUEZ CASALAes_MX
dc.creatorMARIA ESTHER CRUZ BELTRANes_MX
dc.date2016-
dc.date.accessioned2019-01-09T17:06:07Z-
dc.date.available2019-01-09T17:06:07Z-
dc.identifier.urihttp://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17133-
dc.descriptionAbstract: Background Muscarinic receptors (mAChRs) of the preoptic and anterior hypothalamus areas (POA-AHA) regulate ovulation in an asymmetric manner during the estrous cycle. The aims of the present study were to analyze the effects of a temporal blockade of mAChRs on either side of the POA-AHA performed in diestrus-2 rats on ovulation, the levels of estradiol, follicle stimulating hormone (FSH) and luteinizing hormone (LH) and the mechanisms involved in changes in ovulation. Methods Cyclic rats on diestrus-2 day were anesthetized and randomly assigned to the following groups: 1) microinjection of 1 μl of saline or atropine solution (62.5 ng) in the left or right POA-AHA; 2) removal (unilateral ovariectomty, ULO) of the left (L-ULO) or right (R-ULO) ovary, and 3) rats microinjected with atropine into the left or right POA-AHA plus L-ULO or R-ULO. The ovulation rate and the number of ova shed were measured during the predicted estrus, as well as the levels of estradiol, FSH and LH during the predicted proestrus and the effects of injecting synthetic LH-releasing hormone (LHRH) or estradiol benzoate (EB). Results Atropine in the left POA-AHA decreased both the ovulation rate and estradiol and LH levels on the afternoon of proestrus, also LHRH or EB injection restored ovulation. L- or R-ULO resulted in a lower ovulation rate and smaller number of ova shed, and only injection of LHRH restored ovulation. EB injection at diestrus-2 restored ovulation in animals with L-ULO only. The levels of estradiol, FSH and LH in rats with L-ULO were higher than in animals with unilateral laparotomy. In the group microinjected with atropine in the left POA-AHA, ovulation was similar to that in ULO rats. In contrast, atropine in the right POA-AHA of ULO rats blocked ovulation, an action that was restored by either LHRH or EB injection.es_MX
dc.descriptionConclusions: These results indicated that the removal of a single ovary at noon on diestrus-2 day perturbed the neuronal pathways regulating LH secretion, which was mediated by the muscarinic system connecting the right POA-AHA and the ovaries.es_MX
dc.formatAdobe PDFes_MX
dc.languageenges_MX
dc.publisherBioMed Centrales_MX
dc.relationhttps://rbej.biomedcentral.com/articles/10.1186/s12958-016-0208-3es_MX
dc.relation.requiresSies_MX
dc.rightsAcceso Abiertoes_MX
dc.sourceReproductive Biology and Endocrinology (1477-7827) vol. 14 (2016)es_MX
dc.subjectMEDICINA Y CIENCIAS DE LA SALUDes_MX
dc.subjectCiencias médicases_MX
dc.subjectFarmacodinámicaes_MX
dc.subjectCompuestos heterocíclicoses_MX
dc.subjectAlcaloides solanáceoses_MX
dc.subjectAlcaloides de belladonaes_MX
dc.subjectDerivados de atropinaes_MX
dc.subjectAtropinaes_MX
dc.subjectProcedimientos quirúrgicos operativoses_MX
dc.subjectProcedimientos quirúrgicos urogenitaleses_MX
dc.subjectCastraciónes_MX
dc.subjectOvariectomíaes_MX
dc.subjectOvulaciónes_MX
dc.subjectFarmacodynamices_MX
dc.subjectHeterocyclic compoundses_MX
dc.subjectSolanaceous alkaloidses_MX
dc.subjectBelladonna alkaloidses_MX
dc.subjectAtropine derivativeses_MX
dc.subjectAtropinees_MX
dc.subjectSurgical procedures, operativees_MX
dc.subjectUrogenital surgical procedureses_MX
dc.subjectCastrationes_MX
dc.subjectOvariectomyes_MX
dc.subjectOvulationes_MX
dc.titleThe participation of the muscarinic receptors in the preoptic-anterior hypothalamic areas in the regulation of ovulation depends on the ovaryes_MX
dc.typeArtículoes_MX
dc.audienceResearcherses_MX
dc.creator.idEIVF810314MDFSLL02es_MX
dc.creator.idFOAM890115MMCLGR05es_MX
dc.creator.idAICI730724MDFRRS06es_MX
dc.creator.idCALM560503HDFRNR05es_MX
dc.creator.idCARD650511HDFHMV02es_MX
dc.creator.idDOCR390918HNEMSB09es_MX
dc.creator.idCUBE580129MDFRLS07es_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
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