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3-NP-induced Huntington's-like disease impairs Nrf2 activation without loss of cardiac function in aged rats

dc.rights.licensehttp://creativecommons.org/licenses/by/4.0es_MX
dc.creatorALEJANDRO SILVA PALACIOSes_MX
dc.creatorMARCOS OSTOLGA CHAVARRIAes_MX
dc.creatorMABEL BUELNA CHONTALes_MX
dc.creatorCARLOS SANCHEZ GARIBAYes_MX
dc.creatorSauri Hernández Resédizes_MX
dc.creatorFRANCISCO JAVIER ROLDAN GOMEZes_MX
dc.creatorPedro Lorenzo Flores Chavezes_MX
dc.creatorARMANDO LUNA LOPEZes_MX
dc.creatorMINA KONIGSBERG FAINSTEINes_MX
dc.creatorANA CECILIA ZAZUETA MENDIZABALes_MX
dc.date2017
dc.date.accessioned2021-12-15T21:12:37Z
dc.date.available2021-12-15T21:12:37Z
dc.identifier.urihttps://hdl.handle.net/20.500.12100/17349
dc.descriptionCardiovascular diseases (CVDs) are one of the leading causes of death in patients over 60 years with Huntington's disease (HD). Here, we investigated if age-related oxidative stress (OS) is a relevant factor to develop cardiac damage in an in vivo model of striatal neurodegeneration induced by 3-nitropropionic acid (3-NP). We also evaluated the potential effect of tert-butylhydroquinone (tBHQ) to increase the Nrf2-regulated antioxidant response in hearts from adult and aged rats intoxicated with 3-NP. Our results showed that 3-NP-treatment did not induce cardiac dysfunction, neither in adult nor in aged rats. However, at the cellular level, adult animals showed higher susceptibility to 3-NP-induced damage than aged rats, which suggest that chronic oxidative stress ongoing during aging might have induced an hormetic response that probably prevented from further 3-NP damage. We also found that the oxidative unbalance concurs with unresponsiveness of the Nrf2-mediated antioxidant response in old animals.es_MX
dc.formatAdobe PDFes_MX
dc.languageenges_MX
dc.publisherElsevieres_MX
dc.relationhttps://www.sciencedirect.com/science/article/abs/pii/S0531556517303765?via%3Dihub#!es_MX
dc.relation.requiresSies_MX
dc.rightsAcceso Abiertoes_MX
dc.sourceExperimental Gerontology (0531-5565) Vol. 96 (2017)es_MX
dc.subjectMEDICINA Y CIENCIAS DE LA SALUDes_MX
dc.subjectCiencias médicases_MX
dc.subjectCiencias clínicases_MX
dc.subjectGeriatríaes_MX
dc.subjectEnvejecimientoes_MX
dc.subjectAginges_MX
dc.subjectEnvejecidoes_MX
dc.subjectAgedes_MX
dc.subjectFunción cardiacaes_MX
dc.subjectCardiac functiones_MX
dc.subjectHormesises_MX
dc.title3-NP-induced Huntington's-like disease impairs Nrf2 activation without loss of cardiac function in aged ratses_MX
dc.typePreimpresoes_MX
dc.audienceResearcherses_MX
dc.creator.idSIPA890111HDFLLL08es_MX
dc.creator.idOOCM910731HMCSHR09es_MX
dc.creator.idBUCM841215MDFLHB07es_MX
dc.creator.idSAGC850318HMCNRR07es_MX
dc.creator.idCA1343762es_MX
dc.creator.idROGF660127HNELMR06es_MX
dc.creator.idCA1343763es_MX
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dc.creator.idKOFM650625MDFNNN02es_MX
dc.creator.idZAMA611122MDFZNN04es_MX
dc.creator.nameIdentifiercurpes_MX
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