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Relationship of inflammatory profile of elderly patients serum and senescence-associated secretory phenotype with human breast cancer cells proliferation: Role of IL6/IL8 ratio

dc.rights.licensehttp://creativecommons.org/licenses/by/4.0es_MX
dc.creatorBERTHA ALICIA BARAJAS GOMEZes_MX
dc.creatorOSCAR ROSAS CARRASCOes_MX
dc.creatorSANDRA LIZBETH MORALES ROSALESes_MX
dc.creatorGIBRAN PEDRAZA VAZQUEZes_MX
dc.creatorVIRIDIANA YAZMIN GONZALEZ PUERTOSes_MX
dc.creatorTERESA JUAREZ CEDILLOes_MX
dc.creatorJORGE ANTONIO GARCIA ALVAREZes_MX
dc.creatorPablo Damian_Matsumuraes_MX
dc.creatorMINA KONIGSBERG FAINSTEINes_MX
dc.creatorARMANDO LUNA LOPEZes_MX
dc.date2017
dc.date.accessioned2021-12-08T18:59:48Z
dc.date.available2021-12-08T18:59:48Z
dc.identifier.urihttp://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17340
dc.descriptionAging is considered a systemic, chronic and low-grade inflammatory state, called "inflammaging", which has been contemplated as a risk factor for cancer development and progression in the elderly population. Cellular senescence is a multifactorial phenomenon of growth arrest and distorted function, which has been recognized as a contributor to aging. Senescent cells have an altered secretion pattern called Senescent Associated Secretory Phenotype (SASP), that comprise a complex mix of factors including cytokines, growth factors, chemokines and matrix metalloproteinases among others. The SASP secreted by accumulated senescent cells during old age has been related to local inflammation that leads to cellular transformation and therefore may be supporting the inflammaging process. Here, we evaluated if the pro-inflammatory profile within the serum obtained from elderly patients (EPS) was able to induce cellular proliferation in the breast cancer transformed cell line (MCF-7), in a similar way to the proliferation stimulated by the SASP obtained from WI-38 primary cells prematurely induced to senescence by oxidative stress (SIPS). At the same time, the participation of IL-6/IL-8 ratio was determined. Our results showed that not all the EPS increased MCF-7 proliferation. However, there was an interesting relationship between IL-6 and IL-8 concentrations, when the IL-6 was higher than IL-8. Similar results were found with SASP from SIPS-WI-38 on the MCF-7 proliferation. Although it is known that those cytokines are fundamental factors to induce proliferation; the occurrence of other components in the cellular microenvironment is necessary to carry out this effect.es_MX
dc.formatAdobe PDFes_MX
dc.languageenges_MX
dc.publisherElsevier, Academic Press& International Cytokine Societyes_MX
dc.relationhttps://www.sciencedirect.com/science/article/abs/pii/S1043466616305919?via%3Dihubes_MX
dc.relation.requiresSies_MX
dc.rightsAcceso Abiertoes_MX
dc.sourceCytokine (1043-4666) Vol. 91 (2017)es_MX
dc.subjectBIOLOGÍA Y QUÍMICAes_MX
dc.subjectBiología celulares_MX
dc.subjectSenectudes_MX
dc.subjectSenescencees_MX
dc.subjectEnvejecimientoes_MX
dc.subjectAginges_MX
dc.subjectNeoplasias mamariases_MX
dc.subjectBreast neoplasmses_MX
dc.subjectCáncer de mamaes_MX
dc.subjectBreast canceres_MX
dc.titleRelationship of inflammatory profile of elderly patients serum and senescence-associated secretory phenotype with human breast cancer cells proliferation: Role of IL6/IL8 ratioes_MX
dc.typeArtículoes_MX
dc.audienceResearcherses_MX
dc.creator.idBAGB820303MGTRMR03es_MX
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dc.creator.idMORS910315MDFRSN07es_MX
dc.creator.idPEVG910201HHGDZB09es_MX
dc.creator.idGOPV820119MDFNRR03es_MX
dc.creator.idJUCT700926MMCRDR00es_MX
dc.creator.idGAAJ720903HDFRLR02es_MX
dc.creator.id0000-0003-4815-2516es_MX
dc.creator.idKOFM650625MDFNNN02es_MX
dc.creator.idLULA690630HDFNPR02es_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercvues_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX


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