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VNTR polymorphisms of the IL-4 and IL-1RN genes and their relationship with frailty syndrome in Mexican community-dwelling elderly

dc.rights.licensehttp://creativecommons.org/licenses/by/4.0es_MX
dc.creatorTHALIA GABRIELA PEREZ SUAREZes_MX
dc.creatorLUIS MIGUEL FRANCISCO GUTIERREZ ROBLEDOes_MX
dc.creatorJOSE ALBERTO AVILA FUNESes_MX
dc.creatorJOSE LUIS ACOSTA RODRIGUEZes_MX
dc.creatorMONICA ESCAMILLA TILCHes_MX
dc.creatorJORGE RAMON PADILLA GUTIERREZes_MX
dc.creatorNORMA TORRES CARRILLOes_MX
dc.creatorSARA TORRES CASTROes_MX
dc.creatorMARIANA LOPEZ ORTEGAes_MX
dc.creatorJose Francisco Muñoz Vallees_MX
dc.creatorNORA MAGDALENA TORRES CARRILLOes_MX
dc.date2016
dc.date.accessioned2021-12-08T17:54:27Z
dc.date.available2021-12-08T17:54:27Z
dc.identifier.urihttp://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17333
dc.descriptionInflammation is a key event that is closely associated with the pathophysiology of frailty. The relationship of genetic polymorphisms into inflammatory cytokines with frailty remains poorly understood. The aim of this study was to investigate the association between VNTR polymorphisms of the IL-4 and IL-1RN genes with the risk of frailty. We included a sample of 630 community-dwelling elderly aged 70 and older. Both IL-4 and IL-1RN VNTR polymorphisms were genotyped by the polymerase chain reaction (PCR) method. Mean age was 77.7 years (SD = 6.0) and 52.5 % were women. The participants classified as frail were more likely to be older, had lower MMSE score (p < 0.001), and had more disability for IADL (p < 0.001) and ADL (p < 0.001). Genotypic and allelic frequencies for the IL-4 VNTR polymorphism did not show significant differences between study groups (p > 0.05). However, we just observed a significant difference in the allelic frequencies for the A2 allele of the IL-1RN VNTR polymorphism between frail and nonfrail groups (OR 1.84, 95 % CI 1.08-3.12, p = 0.02). In addition, we analyzed the combined effect of the IL-4 and IL-1RN VNTR polymorphisms and their possible association with frailty, where the combined IL-4 (low) -IL-1Ra (high) genotype was identified as a marker of risk to frailty syndrome (OR 7.86, 95 % CI 1.83-33.69, p = 0.006). Our results suggest that both A2 allele and the combined IL-4 (low) -IL-1Ra (high) genotype might be genetic markers of susceptibility to frailty in Mexican elderly.es_MX
dc.formatAdobe PDFes_MX
dc.languageenges_MX
dc.publisherElsevieres_MX
dc.relationhttps://link.springer.com/article/10.1007%2Fs40520-015-0503-4es_MX
dc.relation.requiresSies_MX
dc.rightsAcceso Abiertoes_MX
dc.sourceAging Clinical and Experimental Research (1720-8319) Vol. 28 (2016)es_MX
dc.subjectBIOLOGÍA Y QUÍMICAes_MX
dc.subjectGeriatríaes_MX
dc.subjectPersonas mayoreses_MX
dc.subjectOlder adultses_MX
dc.subjectFragilidades_MX
dc.subjectFrailtyes_MX
dc.subjectPredisposición genéticaes_MX
dc.subjectGenetic susceptibilityes_MX
dc.subjectPolimorfismo VNTRes_MX
dc.subjectVNTR polymorphismes_MX
dc.subjectMéxicoes_MX
dc.subjectMexicoes_MX
dc.titleVNTR polymorphisms of the IL-4 and IL-1RN genes and their relationship with frailty syndrome in Mexican community-dwelling elderlyes_MX
dc.typeArtículoes_MX
dc.audienceResearcherses_MX
dc.creator.idPEST880307MDFRRH08es_MX
dc.creator.idGURL571005HDFTBS14es_MX
dc.creator.idAIFA740503HDFVNL00es_MX
dc.creator.idAORL780820HDFCDS06es_MX
dc.creator.idEATM791117MDFSLN02es_MX
dc.creator.idPAGJ801227HJCDTR02es_MX
dc.creator.idTOCN790129MJCRRR04es_MX
dc.creator.idTOCS780708MJCRSR06es_MX
dc.creator.idLOOM700114MDFPRR09es_MX
dc.creator.idMUVF740830HGRXLR08es_MX
dc.creator.idTOCN800706MJCRRR08es_MX
dc.creator.nameIdentifiercurpes_MX
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