| dc.rights.license | http://creativecommons.org/licenses/by/4.0 | es_MX |
| dc.creator | MARIO ULISES PEREZ ZEPEDA | es_MX |
| dc.creator | EDUARDO CARDENAS CARDENAS | es_MX |
| dc.creator | Matteo Cesari | es_MX |
| dc.creator | ANA PATRICIA NAVARRETE REYES | es_MX |
| dc.creator | LUIS MIGUEL FRANCISCO GUTIERREZ ROBLEDO | es_MX |
| dc.date | 2016 | |
| dc.date.accessioned | 2021-12-06T22:44:21Z | |
| dc.date.available | 2021-12-06T22:44:21Z | |
| dc.identifier.uri | http://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17331 | |
| dc.description | Purpose: Understanding how the convergence between chronic and complex diseases-such as cancer-and emerging conditions of older adults-such as frailty-takes place would help in halting the path that leads to disability in this age group. The objective of this manuscript is to describe the association between a past medical history of cancer and frailty in Mexican older adults.
Methods: This is a nested in cohort case-control study of the Mexican Health and Aging Study. Frailty was categorized by developing a 55-item frailty index that was also used to define cases in two ways: incident frailty (incident >0.25 frailty index score) and worsening frailty (negative residuals from a regression between 2001 and 2012 frailty index scores). Exposition was defined as self-report of cancer between 2001 and 2012. Older adults with a cancer history were further divided into recently diagnosed (<10 years) and remotely diagnosed (>10 years from the initial diagnosis). Odds ratios were estimated by fitting a logistic regression adjusted for confounding variables.
Results: Out of a total of 8022 older adults with a mean age of 70.6 years, the prevalence of a past medical history of cancer was 3.6 % (n = 288). Among these participants, 45.1 % had been diagnosed with cancer more than 10 years previously. A higher risk of incident frailty compared to controls [odds ratio (OR) 1.53 (95 % confidence interval (CI) 1.04-2.26, p = 0.03); adjusted model OR 1.74 (95 % CI 1.15-2.61, p = 0.008)] was found in the group with a recent cancer diagnosis. Also, an inverse association between a remote cancer diagnosis and worsening frailty was found [OR = 0.56 (95 % CI 0.39-0.8), p = 0.002; adjusted model OR 0.61 (95 % CI 0.38-0.99, p = 0.046)].
Conclusions: Cancer is associated with a higher frailty index, with a potential relevant role of the time that has elapsed since the cancer diagnosis.
Implications for cancer survivors: Cancer survivors may be more likely to develop frailty or worsening of the health status at an older age. This relationship seems especially evident among individuals with a recent oncological diagnosis. Health professionals in charge of older adult care should be aware of this association in order to improve outcomes of older adults who survived cancer. | es_MX |
| dc.format | Adobe PDF | es_MX |
| dc.language | eng | es_MX |
| dc.publisher | Springer | es_MX |
| dc.relation | https://link.springer.com/article/10.1007%2Fs11764-016-0519-6 | es_MX |
| dc.relation.requires | Si | es_MX |
| dc.rights | Acceso Abierto | es_MX |
| dc.source | Journal of Cancer Survivorship (1932-2267) Vol. 10 (2016) | es_MX |
| dc.subject | MEDICINA Y CIENCIAS DE LA SALUD | es_MX |
| dc.subject | Ciencias médicas | es_MX |
| dc.subject | Ciencias clínicas | es_MX |
| dc.subject | Geriatría | es_MX |
| dc.subject | Personas mayores | es_MX |
| dc.subject | Older adults | es_MX |
| dc.subject | Oncogeriatría | es_MX |
| dc.subject | Oncogeriatrics | es_MX |
| dc.subject | Fragilidad | es_MX |
| dc.subject | Frailty | es_MX |
| dc.subject | Enfermedades crónicas | es_MX |
| dc.subject | Chronic diseases | es_MX |
| dc.subject | Discapacidad | es_MX |
| dc.subject | Disability | es_MX |
| dc.subject | Cáncer | es_MX |
| dc.subject | Cancer | es_MX |
| dc.subject | México | es_MX |
| dc.subject | Mexico | es_MX |
| dc.title | Cancer and frailty in older adults: A nested case-control study of the Mexican health and aging study | es_MX |
| dc.type | Artículo | es_MX |
| dc.audience | Researchers | es_MX |
| dc.creator.id | PEZM760111HDFRPR07 | es_MX |
| dc.creator.id | CACE840507HDFRRD02 | es_MX |
| dc.creator.id | 0000-0002-0348-3664 | es_MX |
| dc.creator.id | NARA790409MJCVYN08 | es_MX |
| dc.creator.id | GURL571005HDFTBS14 | es_MX |
| dc.creator.nameIdentifier | curp | es_MX |
| dc.creator.nameIdentifier | curp | es_MX |
| dc.creator.nameIdentifier | cvu | es_MX |
| dc.creator.nameIdentifier | curp | es_MX |
| dc.creator.nameIdentifier | curp | es_MX |
