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Microbiota and Aging. A Review and Commentary

dc.rights.licensehttp://creativecommons.org/licenses/by/4.0es_MX
dc.creatorMaría del Carmen García Peñaes_MX
dc.creatorTERESA ALVAREZ CISNEROSes_MX
dc.creatorRicardo Quiroz-Baezes_MX
dc.creatorRobert Friedlandes_MX
dc.date2017
dc.date.accessioned2021-11-17T21:36:26Z
dc.date.available2021-11-17T21:36:26Z
dc.identifier.urihttp://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17316
dc.descriptionAlthough there is a consensus that the dominant species that make up the adult microbiota remains unchanged in elderly people, it has been reported that there are significant alterations in the proportion and composition of the different taxa, leading to reduced microbiota diversity, as well as an increase of enteropathogens that may lead to chronic inflammation. The ageing of mucosal immune and motor systems also contributes to these changes. As the individual ages, there is a loss in the number of Peyer's patches, an altered local capacity of T and B cell functions as well as chronic macrophage activation. Also, environment, diet, place of residence and biogeography are regulatory factors of the microbiota. Communication in the gut-brain-axis is regulated by many intermediaries including diverse metabolites of the microbiota. Microbial changes have been observed in several geriatric diseases, like Parkinson's and Alzheimer's. In addition, evidence has shown that individuals with high frailty scores had a significant reduction on lactobacilli species when compared to non-frail individuals. Oral microbiota may be also especially important because of the opportunities for access to the brain through the olfactory nerve at the roof of the nose or through the abundant innervations of the oral cavity by the trigeminal and other cranial nerves. Also, there are an increasing number of reports that have suggested potential mechanisms by which the microbiota promote human health span and aging. The study of the microbiota represents an important advance in the understanding of the aging process.es_MX
dc.formatAdobe PDFes_MX
dc.languageenges_MX
dc.publisherElsevier & Instituto Mexicano del Seguro Social (IMSS)es_MX
dc.relationhttps://www.sciencedirect.com/science/article/abs/pii/S0188440917302345?via%3Dihub#!es_MX
dc.relation.requiresSies_MX
dc.rightsAcceso Abiertoes_MX
dc.sourceArchives of Medical Research (0188-4409) Vol. 48 (2017)es_MX
dc.subjectMEDICINA Y CIENCIAS DE LA SALUDes_MX
dc.subjectCiencias médicases_MX
dc.subjectCiencias clínicases_MX
dc.subjectGeriatríaes_MX
dc.subjectGeriatricses_MX
dc.subjectMicrobiotaes_MX
dc.subjectEnvejecimientoes_MX
dc.subjectAginges_MX
dc.subjectSistema inmunoinflamatorioes_MX
dc.subjectInmunoinflamatory systemes_MX
dc.subjectFragilidades_MX
dc.subjectFrailtyes_MX
dc.subjectNeurodegeneraciónes_MX
dc.subjectNeurodegenerationes_MX
dc.titleMicrobiota and Aging. A Review and Commentaryes_MX
dc.typeArtículoes_MX
dc.audienceResearcherses_MX
dc.creator.idGAPC560716MDFRXR00es_MX
dc.creator.idAACT791128MDFLSR06es_MX
dc.creator.idCA1242312es_MX
dc.creator.idCA1343752es_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercaes_MX
dc.creator.nameIdentifiercaes_MX


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