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The -319C/+49G/CT60G Haplotype of CTLA-4 Gene Confers Susceptibility to Rheumatoid Arthritis in Mexican Population

dc.rights.licensehttp://creativecommons.org/licenses/by/4.0es_MX
dc.creatorNORMA TORRES CARRILLOes_MX
dc.creatorHeriberto Ontiveros Mercadoes_MX
dc.creatorNORA MAGDALENA TORRES CARRILLOes_MX
dc.creatorISELA PARRA ROJASes_MX
dc.creatorHECTOR RANGEL VILLALOBOSes_MX
dc.creatorMARIA GUADALUPE RAMIREZ DUEÑASes_MX
dc.creatorSERGIO RAMON GUTIERREZ UREÑAes_MX
dc.creatorYeminia Vallees_MX
dc.creatorJose Francisco Muñoz Vallees_MX
dc.date2013
dc.date.accessioned2021-10-28T18:42:10Z
dc.date.available2021-10-28T18:42:10Z
dc.identifier.urihttp://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17290
dc.descriptionSeveral single nucleotide polymorphisms (SNPs) within the CTLA-4 gene and elevated serum levels of soluble CTLA-4 (sCTLA-4) have been associated with autoimmunity including rheumatoid arthritis (RA). In this case–control study, we evaluated the relationship between the −319C/T (rs5742909) and CT60 G/A (rs3087243) SNPs and sCTLA-4 levels in 200 RA patients and 200 control subjects (CS) from Western Mexico. Both SNPs were genotyped with the polymerase chain reaction–restriction fragment length polymorphism technique and the sCTLA-4 levels were quantified using an enzyme-linked immunosorbent assay kit. In addition, we performed a haplotype analysis, including our previous data of the +49A/G (rs231775) SNP. The G/A genotype of the rs3087243 SNP was associated with a decreased risk of RA [odd ratio (OR) 0.61, 95 % confidence interval (CI) 0.38–0.96, p = 0.024]. This protection was also observed in the negative anti-cyclic citrullinated peptide group of RA carriers of the A allele (OR 0.48, 95 % CI 0.22–1.05, p = 0.042). On the contrary, we identified the −319C/+49G/CT60G haplotype of CTLA-4 gene as a risk factor for RA (OR 1.69, 95 % CI 1.13–2.52, p = 0.01). The sCTLA-4 levels were not associated with RA (p = 0.377), but were correlated with the functional disability of these patients (r = 0.282, p = 0.012). However, in CS the C/T genotype of the rs5742909 SNP, as well as the G/G and G/A genotypes of the rs3087243 SNP were associated with higher sCTLA-4 levels (p < 0.001). In conclusion, our results suggest that the −319C/+49G/CT60G haplotype of CTLA-4 gene is a genetic marker of susceptibility to RA in Western Mexico, whereas the rs3087243 SNP confers protection against this disease. Moreover, both SNPs showed an effect on the sCTLA-4 production in our control population. However, further studies are required to evaluate the role of sCTLA-4 in RA, as well as the molecular and functional basis of the association between both CTLA-4 gene SNPs and soluble levels of CTLA-4 in CS.es_MX
dc.formatAdobe PDFes_MX
dc.languageenges_MX
dc.publisherSpringeres_MX
dc.relationhttps://link.springer.com/article/10.1007/s12013-013-9640-6es_MX
dc.relation.requiresSies_MX
dc.rightsAcceso Abiertoes_MX
dc.sourceCell Biochemistry and Biophysics (1559-0283) Vol. 67 (2013)es_MX
dc.subjectBIOLOGÍA Y QUÍMICAes_MX
dc.subjectCiencias de la vidaes_MX
dc.subjectGenéticaes_MX
dc.subjectGenética humanaes_MX
dc.subjectEnfermedades reumáticases_MX
dc.subjectArtritis reumatoidees_MX
dc.subjectRehumatic diseaseses_MX
dc.subjectRheumatoid arthritises_MX
dc.subjectMéxicoes_MX
dc.subjectMexicoes_MX
dc.titleThe -319C/+49G/CT60G Haplotype of CTLA-4 Gene Confers Susceptibility to Rheumatoid Arthritis in Mexican Populationes_MX
dc.typeArtículoes_MX
dc.audienceResearcherses_MX
dc.creator.idTOCN790129MJCRRR04es_MX
dc.creator.idCA1222873es_MX
dc.creator.idTOCN800706MJCRRR08es_MX
dc.creator.idPARI631029MGRRJS09es_MX
dc.creator.idRAVH710505HJCNLC02es_MX
dc.creator.idRADG630714MJCMXD06es_MX
dc.creator.idGUUS601011HJCTRR02es_MX
dc.creator.id0000-0002-0723-6580es_MX
dc.creator.idMUVF740830HGRXLR08es_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercaes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercvues_MX
dc.creator.nameIdentifiercurpes_MX


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