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A noncanonical NF-κB pathway through the p50 subunit regulates Bcl-2 overexpression during an oxidative-conditioning hormesis response

dc.rights.licensehttp://creativecommons.org/licenses/by/4.0es_MX
dc.creatorARMANDO LUNA LOPEZes_MX
dc.creatorVIRIDIANA YAZMIN GONZALEZ PUERTOSes_MX
dc.creatorJacqueline Romero Ontiveroses_MX
dc.creatorJOSE LUIS VENTURA GALLEGOSes_MX
dc.creatorALEJANDRO ZENTELLA DEHESAes_MX
dc.creatorLUIS ENRIQUE GOMEZ QUIROZes_MX
dc.creatorMINA KONIGSBERG FAINSTEINes_MX
dc.date2013
dc.date.accessioned2021-10-28T18:06:49Z
dc.date.available2021-10-28T18:06:49Z
dc.identifier.urihttp://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17287
dc.descriptionCells can respond to damage and stress by activating various repair and survival pathways. One of these responses can be induced by preconditioning the cells with sublethal stress to provoke a prosurvival response that will prevent damage and death, and which is known as hormesis. Bcl-2, an antiapoptotic protein recognized by its antioxidant and prosurvival functions, has been documented to play an important role during oxidative-conditioning hormesis. Using an oxidative-hormetic model, which was previously established in the L929 cell line by subjecting the cells to a mild oxidative stress of 50 μM H₂O₂ for 9 h, we identified two different transductional mechanisms that participate in the regulation of Bcl-2 expression during the hormetic response. These mechanisms converge in activating the nuclear transcription factor NF-κB. Interestingly, the noncanonical p50 subunit of the NF-κB family is apparently the subunit that participates during the oxidative-hormetic response.es_MX
dc.formatAdobe PDFes_MX
dc.languageenges_MX
dc.publisherElsevieres_MX
dc.relationhttps://www.sciencedirect.com/science/article/abs/pii/S0891584913001913?via%3Dihub#!es_MX
dc.relation.requiresSies_MX
dc.rightsAcceso Abiertoes_MX
dc.sourceFree Radical Biology and Medicine (0891-5849) Vol. 63 (2013)es_MX
dc.subjectBIOLOGÍA Y QUÍMICAes_MX
dc.subjectCiencias de la vidaes_MX
dc.subjectBiología celulares_MX
dc.subjectQuímicos inorgánicoses_MX
dc.subjectRadicales libreses_MX
dc.subjectEstrés oxidativoes_MX
dc.subjectHormesises_MX
dc.subjectRespuesta adaptativaes_MX
dc.subjectCell biologyes_MX
dc.subjectInorganic chemicalses_MX
dc.subjectFree radicalses_MX
dc.subjectOxidative stresses_MX
dc.subjectAdaptative responsees_MX
dc.titleA noncanonical NF-κB pathway through the p50 subunit regulates Bcl-2 overexpression during an oxidative-conditioning hormesis responsees_MX
dc.typeArtículoes_MX
dc.audienceResearcherses_MX
dc.creator.idLULA690630HDFNPR02es_MX
dc.creator.idGOPV820119MDFNRR03es_MX
dc.creator.idCA1219043es_MX
dc.creator.idVEGL670518HGRNLS01es_MX
dc.creator.idZEDA570306HDFNHL05es_MX
dc.creator.idGOQL691127HMSMRS00es_MX
dc.creator.idKOFM650625MDFNNN02es_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercaes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX


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