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The +1858C/T PTPN22 gene polymorphism confers genetic susceptibility to rheumatoid arthritis in Mexican population from the Western Mexico

dc.rights.licensehttp://creativecommons.org/licenses/by/4.0es_MX
dc.creatorNORA MAGDALENA TORRES CARRILLOes_MX
dc.creatorYENILEY RUIZ NOAes_MX
dc.creatorGLORIA ESTHER MARTINEZ BONILLAes_MX
dc.creatorSergio Daniel Leyva Torreses_MX
dc.creatorNORMA TORRES CARRILLOes_MX
dc.creatorCLAUDIA AZUCENA PALAFOX SANCHEZes_MX
dc.creatorROSA ELENA NAVARRO HERNANDEZes_MX
dc.creatorHECTOR RANGEL VILLALOBOSes_MX
dc.creatorEDITH OREGON ROMEROes_MX
dc.creatorJose Francisco Muñoz Vallees_MX
dc.date2012
dc.date.accessioned2021-10-26T23:36:34Z
dc.date.available2021-10-26T23:36:34Z
dc.identifier.urihttp://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17281
dc.descriptionIntroduction: Rheumatoid arthritis (RA) is a common autoimmune disease with a complex genetic background. The PTPN22 gene encodes lymphoid tyrosine phosphatase LYP, a potent negative regulator of T cell activation. Polymorphic variants of this gene have previously been associated with various autoimmune disorders. The +1858C/T single-nucleotide polymorphism (SNP) (rs2476601), in the exon 14 of the PTPN22 gene has been associated with susceptibility to RA in several population. Objective: The aim of this work was to investigate whether the +1858C/T of the PTPN22 gene is associated with susceptibility to RA in Western Mexico population. Methods: A total of 309 unrelated RA patients, classified according to American College of Rheumatology (ACR) 1987 criteria, as well as 347 controls residents from Western Mexico were recruited for this study. The DNA samples were genotyped for +1858C/T PTPN22 gene SNP using the PCR-RFLP technique. Antibodies to cyclic citrullinated peptides (anti-CCP) were measured by enzyme-linked immunosorbent assay (ELISA). Results: The frequency of +1858T risk allele was significantly increased in patients with RA compared with controls (p=0.001, OR=2.83, 95%CI=1.50-5.32). To confirm this results we established a comparison between subjects carrying of CT+TT genotypes versus those carrying CC genotype, between both groups (p=0.004, OR=2.65, 95%CI=1.33-5.36). Nevertheless, we not observed association of the +1858C/T PTPN22 gene SNP with clinical activity and functional disability in RA patients. Likewise, the +1858T variant in RA patients seropositive for anti-CCP antibodies, increased the risk for RA (p=0.008, OR=2.5, 95%CI=1.3-5.0) when we compared with controls; however, in the group of seronegative patients, no was found significant difference (p=0.1, OR=2.5, 95%CI=0.9-7.2). Conclusions: Our results support the association of the +1858T risk allele of the +1858C/T PTPN22 polymorphism with susceptibility to RA and confirm that, in combination with anti-CCP antibodies, this SNP influence the autoimmune processes towards a development of RA in Mexican population.es_MX
dc.formatAdobe PDFes_MX
dc.languageenges_MX
dc.publisherElsevier & EFISes_MX
dc.relationhttps://www.sciencedirect.com/science/article/abs/pii/S0165247812001563?via%3Dihubes_MX
dc.relation.requiresSies_MX
dc.rightsAcceso Abiertoes_MX
dc.sourceImmunology Letters (0165-2478) Vol. 147 (2012)es_MX
dc.subjectBIOLOGÍA Y QUÍMICAes_MX
dc.subjectCiencias de la vidaes_MX
dc.subjectGenéticaes_MX
dc.subjectGenética humanaes_MX
dc.subjectGen PTPN22es_MX
dc.subjectPolimorfismoes_MX
dc.subjectAnticuerpos ANTI-CCPes_MX
dc.subjectGeneticses_MX
dc.subjectHuman geneticses_MX
dc.subjectPolymorphismes_MX
dc.titleThe +1858C/T PTPN22 gene polymorphism confers genetic susceptibility to rheumatoid arthritis in Mexican population from the Western Mexicoes_MX
dc.typeArtículoes_MX
dc.audienceResearcherses_MX
dc.creator.idTOCN800706MJCRRR08es_MX
dc.creator.idRUNY800418MNEZXN02es_MX
dc.creator.idMABG610619MZSRNL07es_MX
dc.creator.idCA1218999es_MX
dc.creator.idTOCN790129MJCRRR04es_MX
dc.creator.idPASC750429MMNLNL02es_MX
dc.creator.idNAHR610531MJCVRS03es_MX
dc.creator.idRAVH710505HJCNLC02es_MX
dc.creator.idOERE781004MMNRMD09es_MX
dc.creator.idMUVF740830HGRXLR08es_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercaes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX


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