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The functional class evaluated in rheumatoid arthritis is associated with soluble TGF-β1 serum levels but not with G915C (Arg25Pro) TGF-β1 polymorphism

dc.rights.licensehttp://creativecommons.org/licenses/by/4.0es_MX
dc.creatorJose Francisco Muñoz Vallees_MX
dc.creatorNORA MAGDALENA TORRES CARRILLOes_MX
dc.creatorIRIS PAOLA GUZMAN GUZMANes_MX
dc.creatorNORMA TORRES CARRILLOes_MX
dc.creatorSANDRA LUZ RUIZ QUEZADAes_MX
dc.creatorCLAUDIA AZUCENA PALAFOX SANCHEZes_MX
dc.creatorHECTOR RANGEL VILLALOBOSes_MX
dc.creatorMARIA GUADALUPE RAMIREZ DUEÑASes_MX
dc.creatorISELA PARRA ROJASes_MX
dc.creatorMARY FAFUTIS MORRISes_MX
dc.creatorBLANCA ESTELA BASTIDAS RAMIREZes_MX
dc.creatorANA LAURA PEREIRA SUAREZes_MX
dc.date2012
dc.date.accessioned2021-10-26T22:52:06Z
dc.date.available2021-10-26T22:52:06Z
dc.identifier.urihttp://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17276
dc.descriptionThe influence of genetic factors in rheumatoid arthritis (RA) has been described, including several cytokine genes such as transforming growth factor β (TGF-β) with regulatory effects on lymphocytes, dendritic cells, macrophages, chondrocytes, and osteoblasts, which are important in the RA pathogenesis. The G915C TGF-β1 polymorphism has been associated with soluble TGF-β1 (sTGF-β) serum levels. Thus, we studied the association of G915C (Arg25Pro) TGF-β1 polymorphism with sTGF-β1 serum levels in RA. We enrolled 120 RA patients and 120 control subjects (CS). The G915C TGF-β1 polymorphism was determined by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) method, and sTGF-β1 serum levels were quantified using an ELISA kit. The genotype frequency of G915C TGF-β1 polymorphism in RA and CS was G/G (91.7%), G/C (8.3%), C/C (0%) and G/G (85.8%), G/C (14.2%), C/C (0%), respectively, without significant differences. Moreover, the G/G TGF-β1 genotype carriers presented the highest disability index evaluated for the Spanish HAQ-DI score (P < 0.001). In addition, the sTGF-β1 serum levels were higher in RA (182.2 ng/mL) than CS (160.2 ng/mL), there was not significant difference. However, we found a positive correlation between the sTGF-β1 serum levels and the functional class (r = 0.472, P = 0.023). In conclusion, the G915C (Arg25Pro) TGF-β1 polymorphism is not associated with RA, but the sTGF-β1 serum levels are related with the functional class in RA.es_MX
dc.formatAdobe PDFes_MX
dc.languageenges_MX
dc.publisherSpringeres_MX
dc.relationhttps://link.springer.com/article/10.1007/s00296-010-1624-xes_MX
dc.relation.requiresSies_MX
dc.rightsAcceso Abiertoes_MX
dc.sourceRheumatology International (1437-160X) Vol. 32 (2012)es_MX
dc.subjectBIOLOGÍA Y QUÍMICAes_MX
dc.subjectCiencias de la vidaes_MX
dc.subjectGenéticaes_MX
dc.subjectGenética humanaes_MX
dc.subjectEnfermedades reumáticases_MX
dc.subjectArtritis reumatoidees_MX
dc.subjectPolimorfismoes_MX
dc.subjectTGF-β1es_MX
dc.subjectRheumatic diseaseses_MX
dc.subjectRheumatic arthritises_MX
dc.subjectPolumorphismes_MX
dc.titleThe functional class evaluated in rheumatoid arthritis is associated with soluble TGF-β1 serum levels but not with G915C (Arg25Pro) TGF-β1 polymorphismes_MX
dc.typeArtículoes_MX
dc.audienceResearcherses_MX
dc.creator.idMUVF740830HGRXLR08es_MX
dc.creator.idTOCN800706MJCRRR08es_MX
dc.creator.idGUGI830808MGRZZR12es_MX
dc.creator.idTOCN790129MJCRRR04es_MX
dc.creator.idRUQS700412MJCZZN08es_MX
dc.creator.idPASC750429MMNLNL02es_MX
dc.creator.idRAVH710505HJCNLC02es_MX
dc.creator.idRADG630714MJCMXD06es_MX
dc.creator.idPARI631029MGRRJS09es_MX
dc.creator.idFAMM581110MJCFRR09es_MX
dc.creator.idBARB571117MBCSML01es_MX
dc.creator.idPESA681203MNERRN09es_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX


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