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LKTA and PlpE small fragments fusion protein protect against Mannheimia haemolytica challenge

dc.rights.licensehttp://creativecommons.org/licenses/by/4.0es_MX
dc.creatorCAROLINA GUZMAN BRAMBILAes_MX
dc.creatorMARIA SARAY QUINTERO FABIANes_MX
dc.creatorCELIA GONZALEZ CASTILLOes_MX
dc.creatorALVARO DE OBESO FERNANDEZ DEL VALLEes_MX
dc.creatorBEATRIZ FLORES SAMANIEGOes_MX
dc.creatorGERMAN DE LA MORA RIVASes_MX
dc.creatorARGELIA ESPERANZA ROJAS MAYORQUINes_MX
dc.creatorDANIEL ORTUÑO SAHAGUNes_MX
dc.date2012
dc.date.accessioned2021-10-26T22:22:19Z
dc.date.available2021-10-26T22:22:19Z
dc.identifier.urihttp://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17273
dc.descriptionBovine respiratory disease (BRD) complex is a major cause of economic losses for the cattle backgrounding and feedlot industries. Mannheimia haemolytica is considered the most important pathogen associated with this disease. Vaccines against M. haemolytica have been prepared and used for many decades, but traditional bacterins have failed to demonstrate effective protection and their use has often exacerbated disease in vaccinated animals. Thus, the BRD complex continues to exert a strong adverse effect on the health and wellbeing of stocker and feeder cattle. Therefore, generation of recombinant proteins has been helpful in formulating enhanced vaccines against M. haemolytica, which could confer better protection against BRD. In the present study, we formulated a vaccine preparation enriched with recombinant small fragments of leukotoxin A (LKTA) and outer-membrane lipoprotein (PlpE) proteins, and demonstrated its ability to generate high antibody titers in rabbits and sheep, which protected against M. haemolytica bacterial challenge in mice.es_MX
dc.formatAdobe PDFes_MX
dc.languageenges_MX
dc.publisherElsevieres_MX
dc.relationhttps://www.sciencedirect.com/science/article/abs/pii/S0034528812002123?via%3Dihub#!es_MX
dc.relation.requiresSies_MX
dc.rightsAcceso Abiertoes_MX
dc.sourceResearch in Veterinary Science (0034-5288) Vol. 93 (2012)es_MX
dc.subjectBIOLOGÍA Y QUÍMICAes_MX
dc.subjectCiencias de la vidaes_MX
dc.subjectPatología animales_MX
dc.subjectManheimia haemolytica (inmunología)es_MX
dc.subjectComplejo bovino respiratorioes_MX
dc.subjectLeucotoxinaes_MX
dc.subjectBiological science disciplineses_MX
dc.subjectBiologyes_MX
dc.subjectZoologyes_MX
dc.subjectPasteurellaceaees_MX
dc.subjectManheimia haemolytica (imminology)es_MX
dc.subjectLeukotoxines_MX
dc.titleLKTA and PlpE small fragments fusion protein protect against Mannheimia haemolytica challengees_MX
dc.typeArtículoes_MX
dc.audienceResearcherses_MX
dc.creator.idGUBC840118MSRZRR09es_MX
dc.creator.idQUFS830206MJCNBR01es_MX
dc.creator.idGOCC851209MJCNSL08es_MX
dc.creator.idOEFA841116HJCBRL00es_MX
dc.creator.idFOSB640901MSRLMT02es_MX
dc.creator.idMORG630120HCMRVR03es_MX
dc.creator.idROMA770824MDFJYR00es_MX
dc.creator.idOUSD670529HDFRHN09es_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX


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