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DNA MMR systems, microsatellite instability and antioxidant activity variations in two species of wild bats: Myotis velifer and Desmodus rotundus, as possible factors associated with longevity

dc.rights.licensehttp://creativecommons.org/licenses/by/4.0es_MX
dc.creatorJUAN CRISTOBAL CONDE PEREZ PRINAes_MX
dc.creatorARMANDO LUNA LOPEZes_MX
dc.creatorVIRIDIANA YAZMIN GONZALEZ PUERTOSes_MX
dc.creatorTANIA ZENTENO SAVINes_MX
dc.creatorMIGUEL ANGEL LEON GALVANes_MX
dc.creatorMINA KONIGSBERG FAINSTEINes_MX
dc.date2012
dc.date.accessioned2021-10-26T22:12:28Z
dc.date.available2021-10-26T22:12:28Z
dc.identifier.urihttp://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17272
dc.descriptionThe accumulation of oxidative damage to biomolecules, such as DNA, is known to induce alterations in the cell's mechanisms and structure that might lead to the aging process. DNA mismatch repair system (MMR) corrects base mismatches generated during DNA replication that have escaped the proofreading process. In addition, antioxidant enzymes can reduce reactive oxygen species effects in order to protect cells from oxidizing damage. In order to determine the importance of these associated factors during the aging process, in this study, levels of MMR proteins MSH2 and MLH1, as well as microsatellite markers, were compared in liver, lung, and brain of juvenile, adult, and old, both female and male, individuals from two species of wild bats: the short-lived Myotis velifer and the longer lived Desmodus rotundus. Catalase, glutathione peroxidase, and superoxide dismutase were also analyzed to determine if the antioxidant protection correlates negatively with DNA damage. Antioxidant activities were higher in the longer lived D. rotundus than in M. velifer. Furthermore, old M. velifer but not old D. rotundus bats had reduced MMR levels and increased microsatellite instability. Therefore, although our results correlate the reduced MMR efficiency, the deficient antioxidant activity, and the increase in DNA damage with the aging process, this is not always true for all living organisms.es_MX
dc.formatAdobe PDFes_MX
dc.languageenges_MX
dc.publisherThe American Aging Associationes_MX
dc.relationhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528369/es_MX
dc.relation.requiresSies_MX
dc.rightsAcceso Abiertoes_MX
dc.sourceAge (2509-2723) Vol. 34 (2012)es_MX
dc.subjectBIOLOGÍA Y QUÍMICAes_MX
dc.subjectCiencias de la vidaes_MX
dc.subjectGenéticaes_MX
dc.subjectCitogenética animales_MX
dc.subjectEnvejecimientoes_MX
dc.subjectAntioxidanteses_MX
dc.subjectActividad antioxidantees_MX
dc.subjectFenómenos genéticoses_MX
dc.subjectDaño en el ADNes_MX
dc.subjectGeneticses_MX
dc.subjectGenetic phenomenaes_MX
dc.subjectDNA damagees_MX
dc.subjectAginges_MX
dc.subjectAntioxidantses_MX
dc.titleDNA MMR systems, microsatellite instability and antioxidant activity variations in two species of wild bats: Myotis velifer and Desmodus rotundus, as possible factors associated with longevityes_MX
dc.typeArtículoes_MX
dc.audienceResearcherses_MX
dc.creator.idCOPJ810831HDFNRN03es_MX
dc.creator.idLULA690630HDFNPR02es_MX
dc.creator.idGOPV820119MDFNRR03es_MX
dc.creator.idZEST641023MDFNVN06es_MX
dc.creator.idLEGM680929HDFNLG06es_MX
dc.creator.idKOFM650625MDFNNN02es_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX


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