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Paracrine roles of senescence in promoting tumourigenesis

dc.rights.licensehttp://creativecommons.org/licenses/by/4.0es_MX
dc.creatorJOSE MARIO GONZALEZ MELJEMes_MX
dc.creatorJohn Appses_MX
dc.creatorHelen Fraseres_MX
dc.creatorJuan Pedro Martinez-Barberaes_MX
dc.date2018
dc.date.accessioned2021-10-25T17:14:46Z
dc.date.available2021-10-25T17:14:46Z
dc.identifier.urihttp://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17255
dc.descriptionSenescent cells activate genetic programmes that irreversibly inhibit cellular proliferation, but also endow these cells with distinctive metabolic and signalling phenotypes. Although senescence has historically been considered a protective mechanism against tumourigenesis, the activities of senescent cells are increasingly being associated with age-related diseases, including cancer. An important feature of senescent cells is the secretion of a vast array of pro-inflammatory cytokines, chemokines, and growth factors collectively known as the senescence-associated secretory phenotype (SASP). Recent research has shown that SASP paracrine signalling can mediate several pro-tumourigenic effects, such as enhancing malignant phenotypes and promoting tumour initiation. In this review, we summarise the paracrine activities of senescent cells and their role in tumourigenesis through direct effects on growth and proliferation of tumour cells, tumour angiogenesis, invasion and metastasis, cellular reprogramming and emergence of tumour-initiating cells, and tumour interactions with the local immune environment. The evidence described here suggests cellular senescence acts as a double-edged sword in cancer pathogenesis, which demands further attention in order to support the use of senolytic or SASP-modulating compounds for cancer treatment.es_MX
dc.formatAdobe PDFes_MX
dc.languageenges_MX
dc.publisherSpringer Naturees_MX
dc.relationhttps://www.nature.com/articles/s41416-018-0066-1es_MX
dc.relation.requiresSies_MX
dc.rightsAcceso Abiertoes_MX
dc.sourceBritish Journal of Cancer ( 1532-1827) vol. 118 (2018)es_MX
dc.subjectMEDICINA Y CIENCIAS DE LA SALUDes_MX
dc.subjectCiencias médicases_MX
dc.subjectCiencias clínicases_MX
dc.subjectGeriatríaes_MX
dc.subjectSenectudes_MX
dc.subjectAginges_MX
dc.subjectMicroambiente celulares_MX
dc.subjectCellular microenvironmentes_MX
dc.subjectMicroambiente tumorales_MX
dc.subjectTumor microenvironmentes_MX
dc.subjectSenescencia celulares_MX
dc.subjectCellular senescencees_MX
dc.subjectComunicación paracrinaes_MX
dc.subjectParacrine communicationes_MX
dc.subjectCarcinogenesises_MX
dc.titleParacrine roles of senescence in promoting tumourigenesises_MX
dc.typeArtículoes_MX
dc.audienceResearcherses_MX
dc.creator.idGOMM860414HDFNLR05es_MX
dc.creator.idCA1242286es_MX
dc.creator.idCA1248430es_MX
dc.creator.idCA1242291es_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercaes_MX
dc.creator.nameIdentifiercaes_MX
dc.creator.nameIdentifiercaes_MX


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