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Macrophage migration inhibitory factor -173 G/C polymorphism: A global meta-analysis across the disease spectrum

dc.rights.licensehttp://creativecommons.org/licenses/by/4.0es_MX
dc.creatorOSCAR ILLESCAS POMPOSOes_MX
dc.creatorJUAN CARLOS GOMEZ VERJANes_MX
dc.creatorLIZBETH ESMERALDA GARCIA VELAZQUEZes_MX
dc.creatorTzipe Govezenskyes_MX
dc.creatorMIRIAM RODRIGUEZ SOSAes_MX
dc.date2018
dc.date.accessioned2021-09-21T17:24:39Z
dc.date.available2021-09-21T17:24:39Z
dc.identifier.urihttp://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17250
dc.descriptionHuman macrophage migration inhibitory factor (MIF) is a cytokine that plays a role in several metabolic and inflammatory processes. Single nucleotide polymorphism (SNP) -173 G/C (rs755622) on MIF gene has been associated with numerous diseases, such as arthritis and cancer. However, most of the reports concerning the association of MIF with these and other pathologies are inconsistent and remain quite controversial. Therefore, we performed a meta-analysis from 96 case-control studies on -173 G/C MIF SNP and stratified the data according to the subjects geographic localization or the disease pathophysiology, in order to determine a more meaningful significance to this SNP. The polymorphism was strongly associated with an increased risk in autoimmune-inflammatory, infectious and age-related diseases on the dominant (OR: 0.74 [0.58–0.93], P < 0.01; OR: 0.81 [0.74–0.89], P < 0.0001; and OR: 0.81 [0.76–0.87], P < 0.0001, respectively) and the recessive models (OR: 0.74 [0.57–0.095], P < 0.01; OR: 0.66 [0.48–0.92], P < 0.0154; and OR: 0.70 [0.60–0.82], P < 0.0001, respectively). Also, significant association was found in the geographic localization setting for Asia, Europe and Latin America subdivisions in the dominant (OR: 0.76 [0.69–0.84], P < 0.0001; OR: 0.77 [0.72–0.83], P < 0.0001; OR: 0.61 [0.44–0.83], P-value: 0.0017, respectively) and overdominant models (OR: 0.85 [0.77–0.94], P < 0.0001; OR: 0.80 [0.75–0.86], P < 0.0001; OR: 0.73 [0.63–0.85], P-value: 0.0017, respectively). Afterwards, we implemented a network meta-analysis to compare the association of the polymorphism for two different subdivisions. We found a stronger association for autoimmune than for age-related or autoimmune-inflammatory diseases, and stronger association for infectious than for autoimmune-inflammatory diseases. We report for the first time a meta-analysis of rs755622 polymorphism with a variety of stratified diseases and populations. The study reveals a strong association of the polymorphism with autoimmune and infectious diseases. These results may help direct future research on MIF-173 G/C in diseases in which the relation is clearer and thus assist the search for more plausible applications.es_MX
dc.formatAdobe PDFes_MX
dc.languageenges_MX
dc.publisherFrontierses_MX
dc.relationhttps://www.frontiersin.org/articles/10.3389/fgene.2018.00055/fulles_MX
dc.relation.requiresSies_MX
dc.rightsAcceso Abiertoes_MX
dc.sourceFrontiers in Genetics (1664-8021) vol. 9 (2018)es_MX
dc.subjectBIOLOGÍA Y QUÍMICAes_MX
dc.subjectCiencias médicases_MX
dc.subjectMeta análisises_MX
dc.subjectMeta-analysises_MX
dc.subjectMacrófagoses_MX
dc.subjectMacrophageses_MX
dc.subjectInflamaciónes_MX
dc.subjectInflammationes_MX
dc.subjectEnvejecimientoes_MX
dc.subjectAginges_MX
dc.subjectPoliformismo genéticoes_MX
dc.subjectPolymorphism, genetices_MX
dc.subjectEnfermedades autoinmuneses_MX
dc.subjectAutoimmune diseaseses_MX
dc.titleMacrophage migration inhibitory factor -173 G/C polymorphism: A global meta-analysis across the disease spectrumes_MX
dc.typeArtículoes_MX
dc.audienceResearcherses_MX
dc.creator.idIEPO840506HDFLMS07es_MX
dc.creator.idGOVJ850305HDFMRN07es_MX
dc.creator.idGAVL870814MDFRLZ09es_MX
dc.creator.idCA1242301es_MX
dc.creator.idROSM700227MVZDSR03es_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercaes_MX
dc.creator.nameIdentifiercurpes_MX


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