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TBHQ induces a hormetic response that protects L6 myoblasts against the toxic effect of palmitate

dc.rights.licensehttp://creativecommons.org/licenses/by/4.0es_MX
dc.creatorPEDRO POSADAS RODRIGUEZes_MX
dc.creatorNATALIA ESMERALDA POSADAS RODRIGUEZes_MX
dc.creatorVIRIDIANA YAZMIN GONZALEZ PUERTOSes_MX
dc.creatorRAFAEL TOLEDO PEREZes_MX
dc.creatorJOSE LUIS VENTURA GALLEGOSes_MX
dc.creatorALEJANDRO ZENTELLA DEHESAes_MX
dc.creatorLUIS ENRIQUE GOMEZ QUIROZes_MX
dc.creatorMINA KONIGSBERG FAINSTEINes_MX
dc.creatorARMANDO LUNA LOPEZes_MX
dc.date2020
dc.date.accessioned2021-08-24T21:17:00Z
dc.date.available2021-08-24T21:17:00Z
dc.identifier.urihttp://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17235
dc.descriptionNutritional status, in particular overweight and obesity, as well as sedentarism and high-fat diet consumption, are important risk factors to develop chronic diseases, which have a higher impact on the elderly’s health. Therefore, these nutritional problems have become a concern to human healthspan and longevity. The fatty acids obtained thru the diet or due to fatty acid synthesis during obesity accumulate within the body generating toxicity and cell death. Fat is not only stored in adipose tissue, but it can also be stored in skeletal muscle. Palmitic acid (PA) has been reported as one of the most important saturated free fatty acids; it is associated to chronic oxidative stress and increased mitochondrial ROS production causing cell death by apoptosis. In skeletal muscle, palmitate has been associated with various pathophysiological consequences, which lead to muscle deterioration during aging and obesity. Since molecules that modify redox state have been proven to prevent cellular damage by inducing a hormetic response, the aim of this study was to evaluate if tert-butylhydroquinone (tBHQ) could activate an antioxidant hormetic response that would be able to protect L6 myoblasts from palmitate toxic effect. Our results provide evidence that tBHQ is able to protect L6 myoblasts against the toxicity induced by sodium palmitate due to a synergistic activation of different signaling pathways such as Nrf2 and NF-κB.es_MX
dc.formatAdobe PDFes_MX
dc.languageenges_MX
dc.publisherHindawies_MX
dc.relationhttps://www.hindawi.com/journals/omcl/2020/3123268/es_MX
dc.relation.requiresSies_MX
dc.rightsAcceso Abiertoes_MX
dc.sourceOxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)es_MX
dc.subjectMEDICINA Y CIENCIAS DE LA SALUDes_MX
dc.subjectCiencias médicases_MX
dc.subjectCiencias clínicases_MX
dc.subjectDieta, alimentación y nutriciónes_MX
dc.subjectEstado nutricionales_MX
dc.subjectDietaes_MX
dc.subjectDesordenes nutricionaleses_MX
dc.subjectObesidades_MX
dc.subjectPersonas mayoreses_MX
dc.subjectLongevidades_MX
dc.subjectDiet, food and nutritiones_MX
dc.subjectNutritional statuses_MX
dc.subjectDietes_MX
dc.subjectNutrition disorderses_MX
dc.subjectObesityes_MX
dc.subjectElderlyes_MX
dc.subjectLongevityes_MX
dc.titleTBHQ induces a hormetic response that protects L6 myoblasts against the toxic effect of palmitatees_MX
dc.typeArtículoes_MX
dc.audienceResearcherses_MX
dc.creator.idPORP870528HMCSDD01es_MX
dc.creator.idPORN900117MMCSDT05es_MX
dc.creator.idGOPV820119MDFNRR03es_MX
dc.creator.idTOPR920725HHGLRF02es_MX
dc.creator.idVEGL670518HGRNLS01es_MX
dc.creator.idZEDA570306HDFNHL05es_MX
dc.creator.idGOQL691127HMSMRS00es_MX
dc.creator.idKOFM650625MDFNNN02es_MX
dc.creator.idLULA690630HDFNPR02es_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
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