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Allostatic Load as a Biological Substrate to Intrinsic Capacity: A Secondary Analysis of CRELES

dc.rights.licensehttp://creativecommons.org/licenses/by/4.0es_MX
dc.creatorLUIS MIGUEL FRANCISCO GUTIERREZ ROBLEDOes_MX
dc.creatorROSA ESTELA GARCIA CHANESes_MX
dc.creatorMARIO ULISES PEREZ ZEPEDAes_MX
dc.date2019
dc.date.accessioned2021-08-24T18:04:04Z
dc.date.available2021-08-24T18:04:04Z
dc.identifier.urihttp://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17226
dc.descriptionObjectives Intrinsic capacity (IC) is one of the latest views of positive aging. In its current status lacks a biological substrate amenable to be intervened. The aim of this study was to determine the association of allostatic load (AL) with IC. Design We present a cross-sectional analysis of the Costa Rican Longevity and Healthy Aging Study. Setting This report is from a representative sample of Costa Rican older adults; one of the countries that integrate the Central America region. Participants 2,827, 60-year or older community-dwelling individuals. Methods An IC index was gathered and validated, including different domains: cognitive, psychological, sensory, vitality and locomotion. AL was integrated with: blood pressure, abdominal obesity, body mass index, HDL-cholesterol, glycosylated hemoglobin, DHEAS, cortisol, epinephrine and norepinephrine. AL was grouped in three categories according to the number of abnormal biomarkers (0–1, 2–3 and ≥4). Chronic diseases, socioeconomic level, sex and age were the adjusting variables. Ordinal logistic regression models were estimated in order to test the strength of the association. Results From a total sample of 1,888 individuals, 51% (n=962) were women, 36.4% were in the 60–69 age category. The mean score of the IC index was of 6.6 (±2.2). Odds ratio (OR) of the adjusted models were significant for the group of those with 2–3 abnormal biomarkers of AL (OR 0.67, p=0.007) and also for those with ≥4 (OR 0.56, p=0.002), when compared to the reference group of AL (0–1 abnormal biomarkers). Conclusions and implications AL showed an incremental association with IC, even when adjusted for factors such as socioeconomic status and chronic diseases. Targeting therapeutically AL could potentially improve IC in older adults and therefore decreasing the progression to disability or to overt dependency.es_MX
dc.formatAdobe PDFes_MX
dc.languageenges_MX
dc.publisherSpringer & Serdi-Editionses_MX
dc.relationhttps://link.springer.com/article/10.1007/s12603-019-1251-5es_MX
dc.relation.requiresSies_MX
dc.rightsAcceso Abiertoes_MX
dc.sourceJournal of Nutrition, Health and Aging (1760-4788) Vol. 23 (2019)es_MX
dc.subjectMEDICINA Y CIENCIAS DE LA SALUDes_MX
dc.subjectCiencias médicases_MX
dc.subjectCiencias clínicases_MX
dc.subjectGeriatríaes_MX
dc.subjectMecanismos de comportamiento y comportamientoes_MX
dc.subjectPsicología sociales_MX
dc.subjectEstilo de vida saludablees_MX
dc.subjectEnvejecimiento saludablees_MX
dc.subjectCrecimiento y desarrolloes_MX
dc.subjectEnvejecimientoes_MX
dc.subjectCapacidad intrinsecaes_MX
dc.subjectGeriatricses_MX
dc.subjectBehavior and behavior mechanismses_MX
dc.subjectPsychology, sociales_MX
dc.subjectHealthy lifestylees_MX
dc.subjectHealthy aginges_MX
dc.subjectGrowth and developmentes_MX
dc.subjectAginges_MX
dc.subjectIntrinsic capacityes_MX
dc.titleAllostatic Load as a Biological Substrate to Intrinsic Capacity: A Secondary Analysis of CRELESes_MX
dc.typeArtículoes_MX
dc.audienceResearcherses_MX
dc.creator.idGURL571005HDFTBS14es_MX
dc.creator.idGACR870908MDFRHS04es_MX
dc.creator.idPEZM760111HDFRPR07es_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX


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