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Predicting Mortality Due to SARS-CoV-2: A Mechanistic Score Relating Obesity and Diabetes to COVID-19 Outcomes in Mexico

dc.rights.licensehttp://creativecommons.org/licenses/by-nc/4.0es_MX
dc.creatorOMAR YAXMEHEN BELLO CHAVOLLAes_MX
dc.creatorJESSICA PAOLA BAHENA LOPEZes_MX
dc.creatorNeftali Eduardo Antonio Villaes_MX
dc.creatorARSENIO VARGAS VAZQUEZes_MX
dc.creatorARMANDO GONZALEZ DIAZes_MX
dc.creatorAlejandro Márquez Salinases_MX
dc.creatorCarlos Alberto Fermín Martínezes_MX
dc.creatorJ. Jesús Navejaes_MX
dc.creatorCARLOS ALBERTO AGUILAR SALINASes_MX
dc.date2020
dc.date.accessioned2021-08-23T21:27:39Z
dc.date.available2021-08-23T21:27:39Z
dc.identifier.urihttp://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17215
dc.descriptionBackground The SARS-CoV-2 outbreak poses a challenge to health care systems due to its high complication rates in patients with cardiometabolic diseases. Here, we identify risk factors and propose a clinical score to predict COVID-19 lethality, including specific factors for diabetes and obesity, and its role in improving risk prediction. Methods We obtained data of confirmed and negative COVID-19 cases and their demographic and health characteristics from the General Directorate of Epidemiology of the Mexican Ministry of Health. We investigated specific risk factors associated to COVID-19 positivity and mortality and explored the impact of diabetes and obesity on modifying COVID-19-related lethality. Finally, we built a clinical score to predict COVID-19 lethality. Results Among the 177 133 subjects at the time of writing this report (May 18, 2020), we observed 51 633 subjects with SARS-CoV-2 and 5,332 deaths. Risk factors for lethality in COVID-19 include early-onset diabetes, obesity, chronic obstructive pulmonary disease, advanced age, hypertension, immunosuppression, and chronic kidney disease (CKD); we observed that obesity mediates 49.5% of the effect of diabetes on COVID-19 lethality. Early-onset diabetes conferred an increased risk of hospitalization and obesity conferred an increased risk for intensive care unit admission and intubation. Our predictive score for COVID-19 lethality included age ≥ 65 years, diabetes, early-onset diabetes, obesity, age < 40 years, CKD, hypertension, and immunosuppression and significantly discriminates lethal from non-lethal COVID-19 cases (C-statistic = 0.823). Conclusions Here, we propose a mechanistic approach to evaluate the risk for complications and lethality attributable to COVID-19, considering the effect of obesity and diabetes in Mexico. Our score offers a clinical tool for quick determination of high-risk susceptibility patients in a first-contact scenario.es_MX
dc.formatAdobe PDFes_MX
dc.languageenges_MX
dc.publisherEndocrine Society & Oxford University Presses_MX
dc.relationhttps://academic.oup.com/jcem/article/105/8/2752/5849337es_MX
dc.relation.requiresSies_MX
dc.rightsAcceso Abiertoes_MX
dc.sourceJournal of Clinical Endocrinology and Metabolism (1945-7197) Vol. 105 (2020)es_MX
dc.subjectMEDICINA Y CIENCIAS DE LA SALUDes_MX
dc.subjectCiencias médicases_MX
dc.subjectCiencias clínicases_MX
dc.subjectEnfermedades viraleses_MX
dc.subjectInfección por coronaviruses_MX
dc.subjectCOVID-19es_MX
dc.subjectSíndrome respiratorio agudo severoes_MX
dc.subjectEnfermedades del sistema endócrinoes_MX
dc.subjectDiabeteses_MX
dc.subjectDesordenes nutricionaleses_MX
dc.subjectObesidades_MX
dc.subjectMéxicoes_MX
dc.subjectVirus diseaseses_MX
dc.subjectCoronavirus infectionses_MX
dc.subjectSARS-CoV-2es_MX
dc.subjectSevere Acute Respiratory Syndromees_MX
dc.subjectEndocrine system diseaseses_MX
dc.subjectDiabetes mellituses_MX
dc.subjectNutrition disorderses_MX
dc.subjectObesityes_MX
dc.subjectMexicoes_MX
dc.titlePredicting Mortality Due to SARS-CoV-2: A Mechanistic Score Relating Obesity and Diabetes to COVID-19 Outcomes in Mexicoes_MX
dc.typeArtículoes_MX
dc.audienceResearcherses_MX
dc.creator.idBECO920925HDFLHM05es_MX
dc.creator.idBALJ930827MDFHPS02es_MX
dc.creator.idCA1343917es_MX
dc.creator.idVAVA940920HGRRZR01es_MX
dc.creator.idGODA870730HDFNZR09es_MX
dc.creator.idCA1343931es_MX
dc.creator.idCA1343932es_MX
dc.creator.idCA1343927es_MX
dc.creator.idAUSC611116HDFGLR00es_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercaes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercaes_MX
dc.creator.nameIdentifiercaes_MX
dc.creator.nameIdentifiercaes_MX
dc.creator.nameIdentifiercurpes_MX


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