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Neuroprotective effect of WIN55,212-2 against 3-nitropropionic acid-induced toxicity in the rat brain: involvement of CB1 and NMDA receptors

dc.rights.licensehttp://creativecommons.org/licenses/by-nc/4.0es_MX
dc.creatorMARISOL MAYA LOPEZes_MX
dc.creatorANA LAURA COLIN GONZALEZes_MX
dc.creatorGABRIELA AGUILERA PORTILLOes_MX
dc.creatorMaria Eduarda de Lima Torreses_MX
dc.creatorAna Zilda Ceolin Colpoes_MX
dc.creatorEDGAR RANGEL LOPEZes_MX
dc.creatorJUANA VILLEDA HERNANDEZes_MX
dc.creatorJESUS DANIEL REMBAO BOJORQUEZes_MX
dc.creatorIsaac Túnez Fiñanaes_MX
dc.creatorARMANDO LUNA LOPEZes_MX
dc.creatorROBERTO CARLOS LAZZARINI LECHUGAes_MX
dc.creatorVIRIDIANA YAZMIN GONZALEZ PUERTOSes_MX
dc.creatorPEDRO POSADAS RODRIGUEZes_MX
dc.creatorALEJANDRO SILVA PALACIOSes_MX
dc.creatorMINA KONIGSBERG FAINSTEINes_MX
dc.creatorABEL SANTAMARIA DEL ANGELes_MX
dc.date2017
dc.date.accessioned2019-06-28T16:05:18Z
dc.date.available2019-06-28T16:05:18Z
dc.identifier.urihttp://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17187
dc.descriptionAbstract: The endocannabinoid system (ECS), and agonists acting on cannabinoid receptors (CBr), are known to regulate several physiological events in the brain, including modulatory actions on excitatory events probably through N-methyl-D-aspartate receptor (NMDAr) activity. Actually, CBr agonists can be neuroprotective. The synthetic CBr agonist WIN55,212-2 acts mainly on CB1 receptor. In turn, the mitochondrial toxin 3-nitropropionic acid (3-NP) produces striatal alterations in rats similar to those observed in the brain of Huntington’s disease patients. Herein, the effects of WIN55,212-2 were tested on different endpoints of the 3-NP-induced toxicity in rat brain synaptosomes and striatal tissue. Motor activity was also evaluated. The 3-NP (1 mM)-induced mitochondrial dysfunction and lipid peroxidation was attenuated by WIN55,212-2 (1 µM) in synaptosomal fractions. The intrastriatal bilateral injection of 3-NP (500 nmol/µL) to rats increased lipid peroxidation and locomotor activity, augmented the rate of cell damage, and decreased the striatal density of neuronal cells. These alterations were accompanied by transcriptional changes in the NMDA (NR1 subunit) content. The administration of WIN55212-2 (1 mg/kg, i.p.) to rats for six consecutive days, before the 3-NP injection, exerted preventive effects on all alterations elicited by the toxin. The prevention of the 3-NP-induced NR1 transcriptional alterations by the CBr agonist together with the increase of CB1 content suggest an early reduction of the excitotoxic process via CBr activation. Our results demonstrate a protective role of WIN55,212-2 on the 3-NP-induced striatal neurotoxicity that could be partially related to the ECS stimulation and induction of NMDAr hypofunction, representing an effective therapeutic strategy at the experimental level for further studies.es_MX
dc.formatAdobe PDFes_MX
dc.languageenges_MX
dc.publishere-Century Publishinges_MX
dc.relationhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340665/es_MX
dc.relation.requiresSies_MX
dc.rightsAcceso Abiertoes_MX
dc.sourceAmerican Journal of Translational Research (1943-8141) vol. 9 (2017)es_MX
dc.subjectMEDICINA Y CIENCIAS DE LA SALUDes_MX
dc.subjectTrastornos neurodegenerativoses_MX
dc.subjectEndocannabinoideses_MX
dc.subjectNeuroprotecciónes_MX
dc.subjectAgonistas de los receptores cannabinoideses_MX
dc.subjectNeurodegenerative disorderses_MX
dc.subjectEndocannabinoidses_MX
dc.subjectNeuroprotectiones_MX
dc.subjectCannabinoid receptor agonistses_MX
dc.titleNeuroprotective effect of WIN55,212-2 against 3-nitropropionic acid-induced toxicity in the rat brain: involvement of CB1 and NMDA receptorses_MX
dc.typeArtículoes_MX
dc.audienceResearcherses_MX
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