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Tert-buthylhydroquinone pre-conditioning exerts dual effects in old female rats exposed to 3-nitropropionic acid.

dc.rights.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0es_MX
dc.creatorALEJANDRO SILVA PALACIOSes_MX
dc.creatorANA LAURA COLIN GONZALEZes_MX
dc.creatorSTEFANIE PAOLA LOPEZ CERVANTESes_MX
dc.creatorCecilia Zazuetaes_MX
dc.creatorARMANDO LUNA LOPEZes_MX
dc.creatorABEL SANTAMARIA DEL ANGELes_MX
dc.creatorMINA KONIGSBERG FAINSTEINes_MX
dc.date2017
dc.date.accessioned2019-04-24T15:44:45Z
dc.date.available2019-04-24T15:44:45Z
dc.identifier.urihttp://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17177
dc.descriptionAbstract: The brain is a very susceptible organ to structural and functional alterations caused by oxidative stress and its vulnerability increases with age. Understanding the antioxidant response activated by the transcription factor Nrf2 has become very important in the aging field in order to activate cellular protection. However, the role of Nrf2 inducers during old age has not been completely understood. Our aim was to activate the Nrf2 pathway by pre-treating old rats with a widely used Nrf2-inducer, tert-buthylhydroquinone (tBHQ), prior to 3-nitropropionic acid (3-NP) insult, in order to evaluate its effects at a behavioral, morphological and biochemical levels. 3-NP has been used to reproduce the biochemical and pathophysiological characteristics of Huntington's disease due to an oxidative effect. Our results suggest that tBHQ confers an important protective effect against 3-NP toxicity; nevertheless, Nrf2 seems not to be the main protective pathway associated to neuroprotection. Hormetic responses include the activation of more than one transcription factor. Nrf2 and NFκB are known to simultaneously initiate different cellular responses against stress by triggering parallel mechanisms, therefore NFκB nuclear accumulation was also evaluated.es_MX
dc.formatAdobe PDFes_MX
dc.languageenges_MX
dc.publisherElsevieres_MX
dc.relationhttps://www.sciencedirect.com/science/article/pii/S2213231717301295?via%3Dihubes_MX
dc.relation.requiresSies_MX
dc.rightsAcceso Abiertoes_MX
dc.sourceRedox Biology (2213-2317) vol. 12 (2017)es_MX
dc.subjectMEDICINA Y CIENCIAS DE LA SALUDes_MX
dc.subjectCiencias medicases_MX
dc.subjectCiencias clínicases_MX
dc.subjectGeriatríaes_MX
dc.subjectEnvejecimientoes_MX
dc.subjectLongevidades_MX
dc.subjectFenómenos fisiológicoses_MX
dc.subjectEstrés fisiológicoes_MX
dc.subjectEstrés oxidativoes_MX
dc.subjectGeriatricses_MX
dc.subjectAginges_MX
dc.subjectLongevityes_MX
dc.subjectPhysiological phenomenaes_MX
dc.subjectStress, physiologicales_MX
dc.subjectOxidative stresses_MX
dc.titleTert-buthylhydroquinone pre-conditioning exerts dual effects in old female rats exposed to 3-nitropropionic acid.es_MX
dc.typeArtículoes_MX
dc.audienceResearcherses_MX
dc.creator.idSIPA890111HDFLLL08es_MX
dc.creator.idCOGA860125MDFLNN04es_MX
dc.creator.idLOCS900922MDFPRT08es_MX
dc.creator.id0000-0003-1068-316Xes_MX
dc.creator.idLULA690630HDFNPR02es_MX
dc.creator.idSAAA661010HDFNNB07es_MX
dc.creator.idKOFM650625MDFNNN02es_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercvues_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX


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