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Severe potential drug-drug interactions in older adults with dementia and associated factors

dc.rights.licensehttp://creativecommons.org/licenses/by/4.0es_MX
dc.creatorMichele Bogetties_MX
dc.creatorCESAR GONZALEZ GONZALEZes_MX
dc.creatorTERESA JUAREZ CEDILLOes_MX
dc.creatorSERGIO SANCHEZ GARCIAes_MX
dc.creatorOscar Rosas Carrascoes_MX
dc.date2016
dc.date.accessioned2019-01-14T18:26:21Z
dc.date.available2019-01-14T18:26:21Z
dc.identifier.urihttp://repositorio.inger.gob.mx/jspui/handle/20.500.12100/17158
dc.descriptionAbstract: interactions in older adults with dementia and to examine the factors associated with these interactions. METHOD: This was a cross-sectional study. The enrolled patients were selected from six geriatrics clinics of tertiary care hospitals across Mexico City. The patients had received a clinical diagnosis of dementia based on the current standards and were further divided into the following two groups: those with severe drug-drug interactions (contraindicated/severe) (n=64) and those with non-severe drug-drug interactions (moderate/minor/absent) (n=117). Additional socio-demographic, clinical and caregiver data were included. Potential drug-drug interactions were identified using Micromedex Drug Reax 2.0® database. RESULTS: A total of 181 patients were enrolled, including 57 men (31.5%) and 124 women (68.5%) with a mean age of 80.11±8.28 years. One hundred and seven (59.1%) patients in our population had potential drug-drug interactions, of which 64 (59.81%) were severe/contraindicated. The main severe potential drug-drug interactions were caused by the combinations citalopram/anti-platelet (11.6%), clopidogrel/omeprazole (6.1%), and clopidogrel/aspirin (5.5%). Depression, the use of a higher number of medications, dementia severity and caregiver burden were the most significant factors associated with severe potential drug-drug interactions. CONCLUSIONS: Older people with dementia experience many severe potential drug-drug interactions. Anti-depressants, antiplatelets, anti-psychotics and omeprazole were the drugs most commonly involved in these interactions. Despite their frequent use, anti-dementia drugs were not involved in severe potential drug-drug interactions. The number and type of medications taken, dementia severity and depression in patients in addition to caregiver burden should be considered to avoid possible drug interactions in this population.es_MX
dc.descriptionConclusions: Older people with dementia experience many severe potential drug-drug interactions. Anti-depressants, antiplatelets, anti-psychotics and omeprazole were the drugs most commonly involved inthese interactions. Despite their frequent use, anti-dementia drugs were not involved in severe potentialdrug-drug interactions. The number and type of medications taken, dementia severity and depression inpatients in addition to caregiver burden should be considered to avoid possible drug interactions in thispopulation.es_MX
dc.formatAdobe PDFes_MX
dc.languageenges_MX
dc.publisherUniversidade de Sao Pauloes_MX
dc.relationhttps://www.revistas.usp.br/clinics/article/view/110864es_MX
dc.relation.requiresSies_MX
dc.rightsAcceso Abiertoes_MX
dc.sourceClinics (1980-5322) vol. 71 (2016)es_MX
dc.subjectMEDICINA Y CIENCIAS DE LA SALUDes_MX
dc.subjectCiencias médicases_MX
dc.subjectCiencias clínicases_MX
dc.subjectGeriatríaes_MX
dc.subjectFenómenos fisiológicoses_MX
dc.subjectFenómenos farmacológicos y toxicológicoses_MX
dc.subjectInteracciones con los medicamentoses_MX
dc.subjectEnfermedades del sistema nervioso centrales_MX
dc.subjectEnfermedades cerebraleses_MX
dc.subjectDemenciaes_MX
dc.subjectPersonas mayoreses_MX
dc.subjectGeriatricses_MX
dc.subjectPhysiological phenomenaes_MX
dc.subjectPharmacological and toxicological phenomenaes_MX
dc.subjectDrug interactionses_MX
dc.subjectCentral nervous system diseaseses_MX
dc.subjectBrain diseaseses_MX
dc.subjectDementiaes_MX
dc.subjectElderlyes_MX
dc.titleSevere potential drug-drug interactions in older adults with dementia and associated factorses_MX
dc.typeArtículoes_MX
dc.audienceResearcherses_MX
dc.creator.id0000-0003-1063-4106es_MX
dc.creator.idGOGC710906HJCNNS02es_MX
dc.creator.idJUCT700926MMCRDR00es_MX
dc.creator.idSAGS710328HDFNRR03es_MX
dc.creator.id0000-0002-0564-5882es_MX
dc.creator.nameIdentifiercvues_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifiercurpes_MX
dc.creator.nameIdentifierorcides_MX


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